Results 151 to 160 of about 2,855,386 (298)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

"Toward True Health Care Reform: More Care, Less Insurance" [PDF]

open access: yes
The United States has the most expensive health care system in the world, yet its system produces inferior outcomes relative to those in other countries.
L. Randall Wray, Marshall Auerback
core  

Resilience: Now What? : Comment on "Re-evaluating Our Knowledge of Health System Resilience During COVID-19: Lessons From the First Two Years of the Pandemic"

open access: yes
In this paper we draw upon the review article “Re-evaluating Our Knowledge of Health System Resilience During COVID-19: Lessons from the First Two Years of the Pandemic” by Saulnier et al.
Karreinen, Soila, Kihlström, Laura
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

Universal health coverage in Latin America?

open access: yesSocial Medicine, 2016
This Medicina Social/Social Medicine issue includes, among others, two articles critical of so-called Universal Health Coverage (UHC), one by Mishra and Seshadri and another by Waitzkin.
Asa Cristina Laurell
doaj  

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Oral health coordinators: perception on management and skills in the single health system

open access: yes, 2019
Objetivo: Analizar las percepciones de coordinadores de salud bucal sobre gestión y competencias del Sistema Único de Salud. Métodos: Estudio cualitativo realizado en seis Secretarias Ejecutivas Regionales de Fortaleza, Ceará, Brasil. La recogida de datos se dio en marzo de 2019 a través de entrevistas semiestructuradas con seis cirujanos-odontólogos ...
Bizerril, Davi Oliveira   +3 more
openaire   +1 more source

Model of Thai Traditional Medicine Service in the Tertiary Public Health System of Regional Hospitals Hospitals and General Hospitals in the 12th Area Health Service

open access: yes, 2017
วิทยานิพนธ์ (วท.ม. (การจัดการระบบสุขภาพ))--มหาวิทยาลัยสงขลานครินทร์, 2560This descriptive study aimed to examine current situation and management approach for the development of Thai traditional medicine in the Tertiary Public Health System of Regional ...
ภรณ์ทิพย์ ขุนพิทักษ์
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

open access: yesFEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino   +2 more
wiley   +1 more source

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