Results 51 to 60 of about 7,150,473 (243)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
An Efficient Control of a Series Connected Two-Synchronous Motor 5-Phase with Non Sinusoidal EMF Supplied by a Single 5-leg VSI: Experimental and Theoretical Investigations [PDF]
, 2012 Lien vers la version finale éditeur This paper proposes the control scheme of an original drive which is made up of two 5-phase permanent magnet synchronous machines (PMSM) connected in series.
CHARPENTIER, Jean-Frederic +3 more
core +1 more source
Fault-tolerant operation of single-phase SR generators [PDF]
, 1999 This paper studies fault-tolerant operation of multipole single-phase switched reluctance generators (SRGs), in particular, an 8/8-pole switched reluctance machine.
Sawata, T. +9 more
core +3 more sources
AxiomsWe study single-machine group green scheduling considering group setup time deterioration effects and job-processing time learning effects, where the setup time of a group is a general deterioration function on its starting setup time and the processing ...
Na Yin +4 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
International Journal of Industrial Engineering and Production Research, 2018 In single machine scheduling problems with availability constraints, machines are not available for one or more periods of time. In this paper, we consider a single machine scheduling problem with flexible and periodic availability constraints.
Ghasem Moslehi, Omolbanin Mashkani
doaj +2 more sources
Sidney Machine Tool Company lathe photograph
This photograph shows a lathe at the Sidney Machine Tool Company. Sidney Tool Company was founded in 1905 by Alfred C. Getz in Sidney, Ohio. Getz was also acting plant manager for Monarch Machine Tool, also in Sidney, during the same time.
Sidney Machine Tool Company
core +2 more sources
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source