Results 161 to 170 of about 8,190,383 (300)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A streamlined set-up for Lloyd's mirror interference lithography, using a single-mode-fibre-coupled laser. [PDF]

Microsyst Nanoeng
Lian E, Perivolari E, Liu Y, deMello JC.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Single-mode condition for silicon rib waveguides with large cross sections

, 2004
The single-mode condition for silicon rib waveguides with large cross sections is obtained using a numerical method based on the finite-difference beam propagation method (FD-BPM).
Li YP, Xia JS, Xia, JS, Chinese Acad Sci, Inst Semicond, State Key Lab Integrated Optoelect, Beijing 100083, Peoples R China., Chen SW, Yu JZ   +4 more
core  

Stimulation Modalities in Wearable Haptic Systems: Single-Mode Feedback to Multiphysics Actuation. [PDF]

Research (Wash D C)
Guo X, Avila R, Wu Z, Wang X, Xu P, Ju P, Yang Q, Liu P, Choi S, Andrei N, Xie Z.   +10 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

A microstructured wavefront filter for the Darwin nulling interferometer

The European Space Agency's space-based Darwin mission aims to directly detect extrasolar Earth-like planets using nulling interferometry. However, in order to accomplish this using current optical technology, the interferometer input beams must be ...
Bakalski, I., Foster, M.J., Richardson, D.J., Flanagan, J.C.   +3 more
core   +1 more source

Electrically pumped single-mode microlasers with omnidirectional radiation for optical broadcasting communication. [PDF]

Sci Adv
Xu F, Liu J, Sang Y, Tao T, Kou J, Liu J, Zhi T, Zhuang Z, Zhang R, Liu B.   +9 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Quantum-enhanced multiparameter sensing in a single mode. [PDF]

Sci Adv
Valahu CH, Stafford MP, Huang Z, Matsos VG, Millican MJ, Chalermpusitarak T, Menicucci NC, Combes J, Baragiola BQ, Tan TR.   +9 more
europepmc   +1 more source