Results 141 to 150 of about 10,451,032 (401)
Photonic mode density effects on single-molecule fluorescence blinking [PDF]
, 2007 Fernando D. Stefani +5 more
openalex +1 more source
The role of anharmonic phonons in under-barrier spin relaxation of single molecule magnets
Nature Communications, 2017 The use of single molecule magnets in mainstream electronics requires their magnetic moment to be stable over long times. One can achieve such a goal by designing compounds with spin-reversal barriers exceeding room temperature, namely with large ...
A. Lunghi +3 more
semanticscholar +1 more source
, 2013 Vibrationally coupled electron transport through single-molecule junctions is considered. Reviewing our recent theoretical work, we show that electron-hole pair creation processes represent the key to understand the vibrational excitation characteristic ...
Arroyo +57 more
core +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure
eLifeThe HIV-1 capsid has emerged as a tractable target for antiretroviral therapy. Lenacapavir, developed by Gilead Sciences, is the first capsid-targeting drug approved for medical use.
KM Rifat Faysal +12 more
doaj +1 more source
Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis
eLife, 2018 Uncoating of the metastable HIV-1 capsid is a tightly regulated disassembly process required for release of the viral cDNA prior to nuclear import. To understand the intrinsic capsid disassembly pathway and how it can be modulated, we have developed a ...
Chantal L Márquez +10 more
doaj +1 more source
Current-induced nonequilibrium vibrations in single-molecule devices
, 2006 Finite-bias electron transport through single molecules generally induces nonequilibrium molecular vibrations (phonons). By a mapping to a Fokker-Planck equation, we obtain analytical scaling forms for the nonequilibrium phonon distribution in the limit ...
Abraham Nitzan +5 more
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Functional analysis of the secondary HIV-1 capsid binding site in the host protein cyclophilin A
Retrovirology, 2019 Background Efficient HIV-1 replication depends on interaction of the viral capsid with the host protein cyclophilin A (CypA). CypA, a peptidylprolyl isomerase, binds to an exposed loop in the viral CA protein via the enzyme’s active site.
Wang Peng +9 more
doaj +1 more source
Single‐molecule mass spectrometry
Mass Spectrometry Reviews, 2016 In single‐molecule mass spectrometry, the mass of each ion is measured individually; making it suitable for the analysis of very large, heterogeneous objects that cannot be analyzed by conventional means. A range of single‐molecule mass spectrometry techniques has been developed, including time‐of‐flight with cryogenic detectors, a quadrupole ion trap ...
David Z, Keifer, Martin F, Jarrold
openaire +3 more sources