Results 51 to 60 of about 10,451,032 (401)

Simulated single molecule microscopy with SMeagol

open access: yes, 2016
SMeagol is a software tool to simulate highly realistic microscopy data based on spatial systems biology models, in order to facilitate development, validation, and optimization of advanced analysis methods for live cell single molecule microscopy data ...
Boucharin, Alexis   +4 more
core   +2 more sources

Formation and Evolution of Single Molecule Junctions [PDF]

open access: yes, 2009
We analyze the formation and evolution statistics of single molecule junctions bonded to gold electrodes using amine, methyl sulfide and dimethyl phosphine link groups by measuring conductance as a function of junction elongation.
Hybertsen, M. S.   +7 more
core   +2 more sources

Dynamic Dissection of the Endocytosis of Porcine Epidemic Diarrhea Coronavirus Cooperatively Mediated by Clathrin and Caveolae as Visualized by Single-Virus Tracking

open access: yesmBio, 2021
Emerging and re-emerging coronaviruses cause serious human and animal epidemics worldwide. For many enveloped viruses, including coronavirus, it is evident that breaking the plasma membrane barrier is a pivotal and complex process, which contains ...
Yangyang Li   +5 more
doaj   +1 more source

Precision and accuracy of single-molecule FRET measurements—a multi-laboratory benchmark study [PDF]

open access: yesNature Methods, 2017
Single-molecule Förster resonance energy transfer (smFRET) is increasingly being used to determine distances, structures, and dynamics of biomolecules in vitro and in vivo.
Björn Hellenkamp   +62 more
semanticscholar   +1 more source

Controlling the phase of a light beam with a single molecule

open access: yes, 2011
We employ heterodyne interferometry to investigate the effect of a single organic molecule on the phase of a propagating laser beam. We report on the first phase-contrast images of individual molecules and demonstrate a single-molecule electro-optical ...
A. Renn   +9 more
core   +1 more source

Variations in Cell Surfaces of Estrogen Treated Breast Cancer Cells Detected by A Combined Instrument for Far-Field and Near-Field Microscopy

open access: yesAnalytical Cellular Pathology, 2002
The response of single breast cancer cells (cell line T‐47D) to 17β‐estradiol (E2) under different concentrations was studied by using an instrument that allows to combine far‐field light microscopy with high resolution scanning near‐field (AFM/SNOM ...
P. Perner   +6 more
doaj   +1 more source

Automatic classification and segmentation of single-molecule fluorescence time traces with deep learning

open access: yesNature Communications, 2020
Traces from single-molecule fluorescence microscopy (SMFM) experiments exhibit photophysical artifacts that typically make analysis time-consuming. Here, the authors have developed an easily accessible software, AutoSiM, for two distinct applications of ...
Jieming Li   +3 more
doaj   +1 more source

Dynamical conductance measurement of single molecular junctions with both high-speed and high-precision

open access: yesAIP Advances, 2022
Real-time and rapid monitoring of the electron transport in nanoscale structures is critical for understanding many fundamental phenomena. However, it is not possible to rapidly record the dynamical current that varied across several orders of magnitude ...
Haiyang Liu   +5 more
doaj   +1 more source

Confined environment facilitates stacked conformations in Holliday Junction

open access: yesChemical Physics Impact, 2023
Holliday Junction (HJ) is an important intermediate in homologous recombination and is involved in DNA break repair. It is a highly dynamic structure and transitions between two stacked isomers through an intermediate open conformer. However, the insight
Priya Agarwal   +2 more
doaj   +1 more source

Deep-STORM: super-resolution single-molecule microscopy by deep learning [PDF]

open access: yes, 2018
We present an ultra-fast, precise, parameter-free method, which we term Deep-STORM, for obtaining super-resolution images from stochastically-blinking emitters, such as fluorescent molecules used for localization microscopy.
Elias Nehme   +7 more
semanticscholar   +1 more source

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