Results 61 to 70 of about 1,178,188 (315)

Single molecule force spectroscopy on ligand-DNA complexes: from molecular binding mechanisms to biosensor applications

, 2004
Ros R, Eckel R, Bartels FW, et al. Single molecule force spectroscopy on ligand-DNA complexes: from molecular binding mechanisms to biosensor applications. Journal of Biotechnology.
Baumgarth, Birgit, Wilking, Sven David, Ros, Robert, Bartels, Frank Wilco, Sischka, Andy, Eckel, Rainer, Pühler, Alfred ; https://orcid.org/, Sewald, Norbert ; https://orcid.org/, Becker, Anke, Anselmetti, Dario ; https://orcid.org/   +9 more
core   +1 more source

Hierarchical mechanism of amino acid sensing by the T-box riboswitch

Nature Communications, 2018
Riboswitches on 5′ ends of mRNAs are important for bacterial gene regulation. Here the authors probe the mechanism of a tRNA aminoacylation sensing T-box riboswitch using single-molecule fluorescence microscopy to characterize dynamic solution ...
Krishna C. Suddala, Javier Cabello-Villegas, Malgorzata Michnicka, Collin Marshall, Edward P. Nikonowicz, Nils G. Walter   +5 more
doaj   +1 more source

Automatic classification and segmentation of single-molecule fluorescence time traces with deep learning

Nature Communications, 2020
Traces from single-molecule fluorescence microscopy (SMFM) experiments exhibit photophysical artifacts that typically make analysis time-consuming. Here, the authors have developed an easily accessible software, AutoSiM, for two distinct applications of ...
Jieming Li, Leyou Zhang, Alexander Johnson-Buck, Nils G. Walter   +3 more
doaj   +1 more source

Dynamical conductance measurement of single molecular junctions with both high-speed and high-precision

AIP Advances, 2022
Real-time and rapid monitoring of the electron transport in nanoscale structures is critical for understanding many fundamental phenomena. However, it is not possible to rapidly record the dynamical current that varied across several orders of magnitude ...
Haiyang Liu, Zhikai Zhao, Xueyan Zhao, Maoning Wang, Tianran Zhao, Dong Xiang   +5 more
doaj   +1 more source

Dynamic Dissection of the Endocytosis of Porcine Epidemic Diarrhea Coronavirus Cooperatively Mediated by Clathrin and Caveolae as Visualized by Single-Virus Tracking

mBio, 2021
Emerging and re-emerging coronaviruses cause serious human and animal epidemics worldwide. For many enveloped viruses, including coronavirus, it is evident that breaking the plasma membrane barrier is a pivotal and complex process, which contains ...
Yangyang Li, Jian Wang, Wei Hou, Yanke Shan, Shouyu Wang, Fei Liu   +5 more
doaj   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Confined environment facilitates stacked conformations in Holliday Junction

Chemical Physics Impact, 2023
Holliday Junction (HJ) is an important intermediate in homologous recombination and is involved in DNA break repair. It is a highly dynamic structure and transitions between two stacked isomers through an intermediate open conformer. However, the insight
Priya Agarwal, Sahil Hasan Kabir, Nibedita Pal   +2 more
doaj   +1 more source

Single-molecule optomechanics in “picocavities” [PDF]

Science, 2016
A cool route to nanospectroscopy Confining light to a cavity is often used to enhance the interaction between the light and a particle stored within the cavity. Benz et al. worked with a self-assembled monolayer of biphenyl-4-thiol molecules sandwiched between a gold film and a gold nanoparticle. They used
Benz, F, Schmidt, MK, Dreismann, A, Chikkaraddy, R, Zhang, Y, Demetriadou, A, Carnegie, C, Ohadi, H, De Nijs, B, Esteban, R, Aizpurua, J, Baumberg, JJ   +11 more
openaire   +4 more sources

Venous Thromboembolism in Pediatric Bone Sarcoma Patients: A 10‐Year, Single‐Institution Experience Encompassing the COVID‐19 Pandemic

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Osteosarcoma (OS) and Ewing sarcoma (EWS) are the most common primary bone cancers in children, but acute thrombosis is poorly characterized in this population. Our study evaluated the rates of venous thromboembolism (VTE) and associated risk factors in pediatric patients with bone sarcomas treated over a 10‐year period encompassing
Sarah Kappa, Shou Xu, Mark Zobeck, Sarah E. Sartain, Nino Rainusso, Lisa Wang, Nicole Montgomery, Paige Wheaton, Sarah Whittle   +8 more
wiley   +1 more source

A unifying model for microRNA-guided silencing of messenger RNAs

Nature Communications
Silencing by the miRNA-guided RNA induced silencing complex (miRISC) is dependent on Ago2-chaperoned base pairing between the miRNA 5′ seed (5′S) and a complementary sequence in the 3′ untranslated region of an mRNA.
Tanmay Chatterjee, Shankar Mandal, Sujay Ray, Alexander Johnson-Buck, Nils G. Walter   +4 more
doaj   +1 more source