Results 51 to 60 of about 6,472,690 (313)

Hierarchical mechanism of amino acid sensing by the T-box riboswitch

Nature Communications, 2018
Riboswitches on 5′ ends of mRNAs are important for bacterial gene regulation. Here the authors probe the mechanism of a tRNA aminoacylation sensing T-box riboswitch using single-molecule fluorescence microscopy to characterize dynamic solution ...
Krishna C. Suddala, Javier Cabello-Villegas, Malgorzata Michnicka, Collin Marshall, Edward P. Nikonowicz, Nils G. Walter   +5 more
doaj   +1 more source

Automatic classification and segmentation of single-molecule fluorescence time traces with deep learning

Nature Communications, 2020
Traces from single-molecule fluorescence microscopy (SMFM) experiments exhibit photophysical artifacts that typically make analysis time-consuming. Here, the authors have developed an easily accessible software, AutoSiM, for two distinct applications of ...
Jieming Li, Leyou Zhang, Alexander Johnson-Buck, Nils G. Walter   +3 more
doaj   +1 more source

Dynamical conductance measurement of single molecular junctions with both high-speed and high-precision

AIP Advances, 2022
Real-time and rapid monitoring of the electron transport in nanoscale structures is critical for understanding many fundamental phenomena. However, it is not possible to rapidly record the dynamical current that varied across several orders of magnitude ...
Haiyang Liu, Zhikai Zhao, Xueyan Zhao, Maoning Wang, Tianran Zhao, Dong Xiang   +5 more
doaj   +1 more source

Dynamic Dissection of the Endocytosis of Porcine Epidemic Diarrhea Coronavirus Cooperatively Mediated by Clathrin and Caveolae as Visualized by Single-Virus Tracking

mBio, 2021
Emerging and re-emerging coronaviruses cause serious human and animal epidemics worldwide. For many enveloped viruses, including coronavirus, it is evident that breaking the plasma membrane barrier is a pivotal and complex process, which contains ...
Yangyang Li, Jian Wang, Wei Hou, Yanke Shan, Shouyu Wang, Fei Liu   +5 more
doaj   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Focus on function: Single molecule RNA enzymology [PDF]

, 2007
The ability of RNA to catalyze chemical reactions was first demonstrated 25 years ago with the discovery that group I introns and RNase P function as RNA enzymes (ribozymes).
Mark A. Ditzler, Walter, Nils G., Elvin A. Alemán, Ditzler, Mark A., Alemán, Elvin A., Rueda, David, David Rueda, Nils G. Walter   +7 more
core   +1 more source

Pulling on single molecules [PDF]

Nature Methods, 2012
Single-molecule methods to apply and measure force and displacement are expanding mechanobiology.
openaire   +2 more sources

Confined environment facilitates stacked conformations in Holliday Junction

Chemical Physics Impact, 2023
Holliday Junction (HJ) is an important intermediate in homologous recombination and is involved in DNA break repair. It is a highly dynamic structure and transitions between two stacked isomers through an intermediate open conformer. However, the insight
Priya Agarwal, Sahil Hasan Kabir, Nibedita Pal   +2 more
doaj   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Versatile Control System for Automated Single-Molecule Optical Tweezers Investigations [PDF]

, 2010
We present a versatile control system to automate single-molecule biophysics experiments. This method combines low-level controls into various functional, user-configurable modules, which can be scripted in a domain-specific instruction language.
Steven J. Koch, Richard C. Yeh
core