Results 151 to 160 of about 310,423 (261)

Engineering nanopore in monolayer WS₂ for single-molecule imaging on the atomic-scale flat 2D surfaces. [PDF]

Sci Adv
He H, Zhao M, Xu H, Chang L, Jiang Y, Bai Y, Wang C, Nong H, Ma L, Gan L, Zhang T, Kang F, Liu B, Lei Y.   +13 more
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Single-Molecule Imaging of Wood Xylans on Surfaces and Their Interaction with GH11 Xylanase. [PDF]

Biomacromolecules
Schaubeder JB, Ganser C, Palasingh C, Eibinger M, Nypelö T, Uchihashi T, Spirk S.   +6 more
europepmc   +1 more source

Single-molecule imaging of genome maintenance proteins encountering specific DNA sequences and structures. [PDF]

DNA Repair (Amst), 2023
Irvin EM, Wang H.
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Single-Molecule Imaging and Super-Resolution Microscopy of Lipid Domains in Cell Membranes Using Lipid-Binding Proteins and Fluorophore-Conjugated Lipid Analogs. [PDF]

Membranes (Basel)
Mori T, Suzuki KGN.
europepmc   +1 more source

Single Molecule Imaging of DNA-Protein Interactions Using DNA Curtains. [PDF]

Methods Mol Biol, 2023
Crickard JB.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Deciphering HIV-1 Transcription Initiation and Elongation from Single-Molecule Imaging Data. [PDF]

Research (Wash D C)
Yang X, Wang Z, Shi C, Zhou T, Zhang J.
europepmc   +1 more source