Results 241 to 250 of about 1,211,689 (296)

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Time pressure alters takeoff but not landing biomechanics in single-leg countermovement jumps. [PDF]

PLoS One
Yilmaz U, Celik H, Arpinar-Avsar P.
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Thermo-hydro-mechanical response of energy-piled walls under varying wall configurations, pipe layouts, and seepage conditions. [PDF]

Sci Rep
Villegas L, Narsilio G, Fuentes R.
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Real-time detection of WeChat moments interface blocking behavior and generation of generational user personas based on YOLOv5. [PDF]

Sci Rep
Yu Y, Wang Y, Liu R.
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

PhaseGen: exact solutions for time-inhomogeneous multivariate coalescent distributions under diverse demographies. [PDF]

Genetics
Sendrowski J, Hobolth A.
europepmc   +1 more source

Cation-Induced Dipole Moments on Single-Crystal Metal Surfaces

The Journal of Physical Chemistry C
Fabiola Domínguez-Flores, Axel Groß, Wolfgang Schmickler   +2 more
openaire   +1 more source

Reply to van Haastert: Local competition between Ras/actin-driven protrusions. [PDF]

Proc Natl Acad Sci U S A
Alonso A, Kirkegaard JB, Endres RG.
europepmc   +1 more source