Results 71 to 80 of about 354,091 (262)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Forecasting India’s Electricity Demand Using a Range of Probabilistic Methods

Energies, 2019
With serious energy poverty, especially concerning power shortages, the economic development of India has been severely restricted. To some extent, power exploitation can effectively alleviate the shortage of energy in India.
Yeqi An, Yulin Zhou, Rongrong Li
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Perhitungan Peramalan Pengadaan Obat Menggunakan Metode Single Exponential Smoothing Dan Single Moving Average Pada Unit Farmamin Dinas Kesehatan Provinsi Jawa Tengah

JOINS (Journal of Information System), 2017
Abstrak Ketidakstabilan jumlah setiap jenis obat yang disediakan oleh Dinas Kesehatan Provinsi Jawa Tengah untuk setiap Kabupaten/Kota dikarenakan masih dilakukan secara konvensional yaitu hanya dengan melakukan perhitungan manual dengan menjumlahkan
Lintang Mekar Tanjung, Amiq Fahmi
doaj  

Should Single-Equation Dynamic Gasoline Demand Models Include Moving Average Terms?

SSRN Electronic Journal, 2008
We argue that single-equation dynamic demand models applied to estimating gasoline demand should capture the slow evolution of unobservable habits that in part determine vehicle and gasoline usage. Inclusion of unobservable habits implies that single-equation models should include moving-average terms.
openaire   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Prediction of Bread Raw Material Stock At Al-Fattah Bakery and Cake Aek Teluk Kiri using SMA method

Sistemasi: Jurnal Sistem Informasi
AL- Fattah Bakery and Cake is a company engaged in the production and sale of pastries. In managing raw material inventory, you must ensure sufficient inventory for sales, minimizing the time and costs required. Inventory control is an effort carried out
Dewi Handayani, Masitah Handayani, Abdul Karim Syahputra   +2 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Moving-average processing enables accurate quantification of time delay and compares the trending ability of cardiac output monitors with different response times

BMC Biomedical Engineering
Background Continuous cardiac output (CCO) monitoring using pulmonary artery (PA) thermodilution and newly introduced beat-to-beat cardiac output (CO) monitoring technologies exhibits different response time delays.
Yoshihiro Sugo, Ryoichi Ochiai
doaj   +1 more source