Results 121 to 130 of about 8,186,016 (282)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Implementing a single‐person virtual Trier social stress test via zoom: validation and outcomes

Stress
The Trier Social Stress Test (TSST) reliably induces psychosocial stress, but its high resource demands limit its applicability in many research contexts.
Lynn Sablottny, Brunna Tuschen-Caffier
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The second Global Conference on Person-Centred Care: Bridging Practice, Organisation and Governance

This is the abstract book for the second Global Conference on Person-Centred Care (GCPCC) with the theme Bridging Practice, Organisation and Governance.

core  

A two for one special: EEG hyperscanning using a single-person EEG recording setup. [PDF]

MethodsX, 2023
Douglas CL, Tremblay A, Newman AJ.
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Introduction to Person-Centered Psychiatry

, 2017
Having the whole person as the center and goal of health and health care may be seen as the core concept of person-centered psychiatry and, more broadly, person-centered medicine.
Botbol, Michel, Michel Botbol, Juan E. Mezzich, Salloum, Ihsan M, C. Robert Cloninger, George N. Christodoulou, Christodoulou, George N, Ihsan M. Salloum, Mezzich, Juan E, Cloninger, C. Robert   +9 more
core   +1 more source

Single-Person Reduction of Ipsilateral Elbow, Lunate, and Scaphoid Dislocation: A Review of the Literature. [PDF]

J Hand Surg Glob Online, 2023
Fulton Z, Butler J, Porter S, Hiatt J, Patel A.   +4 more
europepmc   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source