Results 231 to 240 of about 2,012,724 (325)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Physical-MAC Layer Integration: A Cross-Layer Sensing Method for Mobile UHF RFID Robot Reading States Based on MLR-OLS and Random Forest. [PDF]

Sensors (Basel)
Pan R, Qin B, Liu J, Gou H, Liu X, Wang H, Zhou Y.   +6 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Tirzepatide for fertility-sparing treatment in obese/overweight patients with endometrial cancer and atypical hyperplasia: a phase II single-arm clinical trial protocol. [PDF]

BMJ Open
Zheng J, Yang J, Yang J.
europepmc   +1 more source

Clinical Pharmacology Perspective on Direct-To-Subcutaneous Dosing of T Cell Engagers in Oncology First-In-Human Studies. [PDF]

Clin Transl Sci
Qiao W, Shahraz A, Vishwanathan K, Sawant-Basak A.   +3 more
europepmc   +1 more source

Major Histocompatibility Complex Immunogenetic Diversity Differs Substantially Across Sea Turtle Species and Genomic Regions. [PDF]

Genome Biol Evol
Martin KR, Adkins JL, Chea V, Sarkis CM, Phillips KF, Forsman AM, Seney EE, Komoroske LM, Mansfield KL, Savage AE.   +9 more
europepmc   +1 more source

A predictive quality assurance model for patient-specific gamma passing rate of hyperarc-based stereotactic radiotherapy and radiosurgery of brain metastases. [PDF]

J Appl Clin Med Phys
McCarthy S, Harrison B, Pokhrel D.
europepmc   +1 more source

Designing the Bayesian single sampling plan through Markov process

International Journal of Statistics and Applied Mathematics
Dr. V Kaviyarasu, E Karthick
openaire   +1 more source

Bias-aware Oxygen Saturation Index in Critical Care: A Standards-first Framework to Make a Useful Tool Truly Fair. [PDF]

Indian J Crit Care Med
Vijayasimha M.
europepmc   +1 more source