Results 41 to 50 of about 3,199,416 (302)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Stability of singular jump-linear systems with a large state space : a two-time-scale approach [PDF]

, 2012
This paper considers singular systems that involve both continuous dynamics and discrete events with the coefficients being modulated by a continuous-time Markov chain. The underlying systems have two distinct characteristics.
Yuan, Chenggui, Yin, G., Mao, Xuerong, Nguyen, Dung Tien   +3 more
core   +4 more sources

Function spaces on singular manifolds [PDF]

Mathematische Nachrichten, 2012
AbstractIt is shown that most of the well‐known basic results for Sobolev‐Slobodeckii and Bessel potential spaces, known to hold on bounded smooth domains in \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}${\mathbb R}^n$\end{document}, continue to be valid on a wide class of Riemannian manifolds with singularities and ...
openaire   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Singular vector expansion functions for finite methods [PDF]

, 2005
This paper describes the fundamental properties of new singular vector bases that incorporate the edge conditions in curved triangular elements. The bases are fully compatible with the interpolatory or hierarchical high-order regular vector bases used in
Graglia, Roberto, Lombardi, Guido
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The Fractional Laguerre Equation: Series Solutions and Fractional Laguerre Functions

Frontiers in Applied Mathematics and Statistics, 2019
In this paper, we propose a fractional generalization of the well-known Laguerre differential equation. We replace the integer derivative by the conformable derivative of order 0 < α < 1. We then apply the Frobenius method with the fractional power
Rasha Shat, Safa Alrefai, Islam Alhamayda, Alaa Sarhan, Mohammed Al-Refai, Mohammed Al-Refai   +5 more
doaj   +1 more source

Algebraic singular functions are not always dense in the ideal of C∗‐singular functions

Bulletin of the London Mathematical Society
Abstract We give the first examples of étale (non‐Hausdorff) groupoids whose ‐algebras contain singular elements that cannot be approximated by singular elements in . We provide two examples: one is a bundle of groups and the other a minimal and effective groupoid constructed from a self‐similar action on an infinite alphabet ...
Martínez, Diego, Szakács, Nóra
openaire   +2 more sources