Results 41 to 50 of about 166,500 (329)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Multiplicity of Positive Solutions for a Singular Tempered Fractional Initial-Boundary Value Problem with Changing-Sign Perturbation Term

Fractal and Fractional
In this paper, we focus on the multiplicity of positive solutions for a singular tempered fractional initial-boundary value problem with a p-Laplacian operator and a changing-sign perturbation term.
Xinguang Zhang, Peng Chen, Lishuang Li, Yonghong Wu   +3 more
doaj   +1 more source

Approximate solution to a hybrid model with stochastic volatility: a singular-perturbation strategy [PDF]

, 2009
We study a hybrid model of Schobel-Zhu-Hull-White-type from a singular-perturbation-analysis perspective. The merit of the paper is twofold: On one hand, we find boundary conditions for the deterministic non-linear degenerate parabolic partial ...
Fatima, T, Grzelak, L, Hendriks, H
core  

On fractional powers of singular perturbations of the Laplacian

, 2017
We qualify a relevant range of fractional powers of the so-called Hamiltonian of point interaction in three dimensions, namely the singular perturbation of the negative Laplacian with a contact interaction supported at the origin.
Georgiev, Vladimir, Michelangeli, Alessandro, Scandone, Raffaele   +2 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Algebraic Perturbation Theorems of Core Inverse A㊮ and Core-EP Inverse A㊯

Journal of Mathematics, 2023
In this paper, the algebraic perturbation theorems of the core inverse A㊮ and core-EP inverse A㊯ are discussed for a square singular matrix A with different indices, and the expressions of the algebraic perturbation for these two new generalized inverses
Xingping Sheng
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Singular Perturbation Theory for PWM AC/DC Converters: Cascade Nonlinear Control Design and Stability Analysis

Iranian Journal of Electrical and Electronic Engineering, 2022
In this paper, the problem of controlling PWM single-phase AC/DC converters is addressed. The control objectives are twofold: (i) regulating the output voltage to a selected reference value, and (ii) ensuring a unitary power factor by forcing the grid ...
Y. Mchaouar, A. Abouloifa, I. Lachkar, H. Katir, F. Giri, A. El Aroudi, A. Elallali, C. Taghzaoui   +7 more
doaj  

Observability of Discrete-Time Two-Time-Scale Multi-Agent Systems with Heterogeneous Features under Leader-Based Architecture

Mathematics, 2023
This paper investigates the observability of discrete-time two-time-scale multi-agent systems with heterogeneous features under leader–follower architecture. First, a singular perturbation difference model for the discussed system is established based on
Mengqi Gu, Guo-Ping Jiang
doaj   +1 more source