Results 61 to 70 of about 16,736 (301)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Transition of phase response properties and singularity in the circadian limit cycle of cultured cells. [PDF]

PLoS ONE, 2017
The circadian system has been regarded as a limit cycle oscillator constructed by the integrated interaction of clock genes and proteins. Here, we investigated a mammalian circadian oscillation geometrically before and after a perturbation.
Satoshi Koinuma, Hiroshi Kori, Isao T Tokuda, Kazuhiro Yagita, Yasufumi Shigeyoshi   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Period function of planar turning points

Electronic Journal of Qualitative Theory of Differential Equations, 2021
This paper is devoted to the study of the period function of planar generic and non-generic turning points. In the generic case (resp. non-generic) a non-degenerate (resp.
Renato Huzak, David Rojas
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Singular perturbation approximation of semistable linear systems [PDF]

, 2013
This paper proposes a singular perturbation approximation for semistable linear systems. In particular, we derive a novel expression of error systems in the Laplace domain. As a result, we obtain an h2-error bound in terms of the sum of eigenvalues of an
Ishizakiy, T., Sandberg, Henrik,, Aihara, K., Johansson, Karl Henrik,, Imura, J. -I, Kashima, K.   +5 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Multi-Peak Solutions for a Wide Class of Singular Perturbation Problems [PDF]

, 1999
In this paper we are concerned with a wide class of singular perturbation problems arising from such diverse fields as phase transitions, chemotaxis, pattern formation, population dynamics and chemical reaction theory.
Winter, M, Juncheng Wei, Matthias Winter, Wei, J   +3 more
core  

Numerical Integration Scheme Using Singular Perturbation Method [PDF]

, 2013
Some multi degree-of-freedom dynamical systems exhibit a response that contain fast and slow variables. An example of such systems is a multibody system with rigid and deformable bodies. Standard numerical integration of the resultant equations of motion
Parviz E. Nikravesh, Gil, Gibin, Nikravesh, Parviz E, Sanfelice, Ricardo G, Gibin Gil, Ricardo G. Sanfelice   +5 more
core   +1 more source