Results 41 to 50 of about 10,030 (215)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Algebraic Perturbation Theorems of Core Inverse A㊮ and Core-EP Inverse A㊯

Journal of Mathematics, 2023
In this paper, the algebraic perturbation theorems of the core inverse A㊮ and core-EP inverse A㊯ are discussed for a square singular matrix A with different indices, and the expressions of the algebraic perturbation for these two new generalized inverses
Xingping Sheng
doaj   +1 more source

Observability of Discrete-Time Two-Time-Scale Multi-Agent Systems with Heterogeneous Features under Leader-Based Architecture

Mathematics, 2023
This paper investigates the observability of discrete-time two-time-scale multi-agent systems with heterogeneous features under leader–follower architecture. First, a singular perturbation difference model for the discussed system is established based on
Mengqi Gu, Guo-Ping Jiang
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Singular Perturbation Theory for PWM AC/DC Converters: Cascade Nonlinear Control Design and Stability Analysis

Iranian Journal of Electrical and Electronic Engineering, 2022
In this paper, the problem of controlling PWM single-phase AC/DC converters is addressed. The control objectives are twofold: (i) regulating the output voltage to a selected reference value, and (ii) ensuring a unitary power factor by forcing the grid ...
Y. Mchaouar, A. Abouloifa, I. Lachkar, H. Katir, F. Giri, A. El Aroudi, A. Elallali, C. Taghzaoui   +7 more
doaj  

Transition of phase response properties and singularity in the circadian limit cycle of cultured cells. [PDF]

PLoS ONE, 2017
The circadian system has been regarded as a limit cycle oscillator constructed by the integrated interaction of clock genes and proteins. Here, we investigated a mammalian circadian oscillation geometrically before and after a perturbation.
Satoshi Koinuma, Hiroshi Kori, Isao T Tokuda, Kazuhiro Yagita, Yasufumi Shigeyoshi   +4 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source