Results 51 to 60 of about 1,163,546 (321)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Regular and singular perturbations of upper semicontinuous differential inclusion

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1997
In the paper we study the continuity properties of the solution set of upper semicontinuous differential inclusions in both regularly and singularly perturbed case.
Tzanko Donchev, Vasil Angelov
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Perturbations in a Bouncing Brane Model

open access: yes, 2004
The question of how perturbations evolve through a bounce in the Cyclic and Ekpyrotic models of the Universe is still a matter of ongoing debate. In this report we show that the collision between boundary branes is in most cases singular even in the full
G. Veneziano   +5 more
core   +1 more source

Root system of singular perturbations of the harmonic oscillator type operators [PDF]

open access: yes, 2015
We analyze perturbations of the harmonic oscillator type operators in a Hilbert space H, i.e. of the self-adjoint operator with simple positive eigenvalues $\mu_k$ satisfying $\mu_{k+1}-\mu_k \geq \Delta >0$.
Mityagin, Boris, Siegl, Petr
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Non-Singular Finite Time Tracking Control Approach Based on Disturbance Observers for Perturbed Quadrotor Unmanned Aerial Vehicles

open access: yesSensors, 2022
In this paper, a disturbance observer based on the non-singular terminal sliding mode control method was presented for the quadrotor in the presence of wind perturbation. First, the position and attitude dynamical equation of the quadrotor was introduced
Fayez F. M. El-Sousy   +6 more
doaj   +1 more source

Singular perturbations with multiple poles of the simple polynomials

open access: yes, 2016
In this article, we study the dynamics of the following family of rational maps with one parameter: \begin{equation*} f_\lambda(z)= z^n+\frac{\lambda^2}{z^n-\lambda}, \end{equation*} where $n\geq 3$ and $\lambda\in\mathbb{C}^*$.
Xiao, Yingqing, Yang, Fei
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Ultraviolet asymptotics and singular dynamics of AdS perturbations [PDF]

open access: yes, 2015
A bstractImportant insights into the dynamics of spherically symmetric AdS-scalar field perturbations can be obtained by considering a simplified time-averaged theory accurately describing perturbations of amplitude ε on time-scales of order 1/ε2.
B. Craps, O. Evnin, J. Vanhoof
semanticscholar   +1 more source

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