Results 61 to 70 of about 592,249 (330)

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Solutions of some Monge-Amp\`ere equations with isolated and line singularities [PDF]

, 2013
In this paper, we study existence, regularity, classification, and asymptotical behaviors of solutions of some Monge-Amp\`ere equations with isolated and line singularities.
Jin, Tianling, Xiong, Jingang
core  

Multiple perturbations of a singular eigenvalue problem

, 2015
We study the perturbation by a critical term and a $(p-1)$-superlinear subcritical nonlinearity of a quasilinear elliptic equation containing a singular potential. By means of variational arguments and a version of the concentration-compactness principle
Cencelj, Matija, Repovš, Dušan, Virk, Žiga   +2 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

ON SINGULAR SOLUTIONS OF CLAIRAUT EQUATIONS IN THE THEORY OF ORDINARY DIFFERENTIAL AND PARTIAL DERIVATIVE EQUATIONS

Известия высших учебных заведений. Поволжский регион: Физико-математические науки, 2020
Background. There is no problem in finding a general solution to the ordinary differential Clairaut equation. The corresponding procedure is described in details in the theory of ordinary differential equations.
L. A. Zhidova
doaj   +1 more source

Singularity of solutions to singular SPDEs

Building on the notes [Hai17], we give a sufficient condition for the marginal distribution of the solution of singular SPDEs on the $d$-dimensional torus to be singular with respect to the law of the Gaussian measure induced by the linearised equation.
Hairer, Martin, Kusuoka, Seiichiro, Nagoji, Hirotatsu   +2 more
openaire   +2 more sources

Approximate solution of singular integral equations

Applied Mathematics Letters, 2004
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Chakrabarti, A, Berghe, Vanden G
openaire   +2 more sources

Geometric gradient-flow dynamics with singular solutions

, 2008
The gradient-flow dynamics of an arbitrary geometric quantity is derived using a generalization of Darcy's Law. We consider flows in both Lagrangian and Eulerian formulations.
Arnold, Bloch, Bloch, Camassa, Cesare Tronci, Chae, Chandrasekhar, Constantin, Craik, Córdoba, Darryl D. Holm, de Gennes, Debye, Fringer, Grmela, Grzybowski, Holm, Holm, Holm, Holm, Holm, Holm, Holm, Holm, Horstmann, Kandrup, Kaufman, Keller, Marsden, Marsden, Matthaeus, Moffat, Morrison, Rasetti, Saffman, Taylor, Vakhtang Putkaradze, Vallis, Woltjer, Öttinger   +39 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source