Results 71 to 80 of about 585,491 (281)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Singular solutions of doubly singular parabolic equations with absorption
Electronic Journal of Differential Equations, 2000 In this paper we study a doubly singular parabolic equation with absorption, $$ u_t = hbox{ m div} ( |abla u^m|^{p-2}abla u^m ) -u^q $$ with $m>0$, $p>1$, $m(p-1)1$.
Yuanwei Qi, Mingxin Wang
doaj
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Exact solutions and singularities in string theory [PDF]
Physical Review D, 1994 We construct two new classes of exact solutions to string theory which are not of the standard plane wave or gauged WZW type. Many of these solutions have curvature singularities. The first class includes the fundamental string solution, for which the string coupling vanishes near the singularity.
Horowitz, G. T., Tseytlin, A. A.
openaire +3 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Advances in Nonlinear Analysis, 2018 We study the semilinear elliptic ...
Ghergu Marius +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
The Singularities of the Solutions of the Cauchy Problem
Publications of the Research Institute for Mathematical Sciences, 1969 This paper is concerned with the Cauchy problem of linear partial differential equation with holomorphic coefficients in complex domain. The Cauchy-Kowalewski theorem asserts that locally there exists a unique holomorphic solution of the Cauchy problem provided that the initial surface is non-character istic and the initial data are holomorphic.
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Iterative Solution of Singular Systems with Applications [PDF]
, 2014 This paper deals with efficient solution of singular symmetric positive semidefinite problems. Our motivation arises from the need to solve special problems of geotechnics, e.g. to perform upscaling analysis of geocomposites. In that and other applications we have to solve boundary problems with pure Neumann boundary conditions.
Blaheta, R. (Radim) +2 more
openaire +2 more sources