Results 61 to 70 of about 3,020,455 (306)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
On singular solutions for second order delayed differential equations
Electronic Journal of Qualitative Theory of Differential Equations, 2012 Asymptotic properties and estimate of singular solutions (either defined on a finite interval only or trivial in a neighbouhood of infinity) of the second order delay differential equation with p-Laplacian are investigated.
Miroslav Bartusek
doaj +1 more source
Singularity of solutions to singular SPDEs
Building on the notes [Hai17], we give a sufficient condition for the marginal distribution of the solution of singular SPDEs on the $d$-dimensional torus to be singular with respect to the law of the Gaussian measure induced by the linearised equation.
Hairer, Martin +2 more
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Iterative Solution of Singular Systems with Applications [PDF]
, 2014 This paper deals with efficient solution of singular symmetric positive semidefinite problems. Our motivation arises from the need to solve special problems of geotechnics, e.g. to perform upscaling analysis of geocomposites. In that and other applications we have to solve boundary problems with pure Neumann boundary conditions.
Blaheta, R. (Radim) +2 more
openaire +3 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Positive solutions for a class of singular boundary-value problems
Electronic Journal of Differential Equations, 2006 This paper concerns the existence and multiplicity of positive solutions for Sturm-Liouville boundary-value problems. We use fixed point theorems and the sub-super solutions method to two solutions to the problem studied.
Dang Dinh Hai
doaj
Singularities of the solution of the Cauchy problem
, 2017 In this chapter, we use the formula for the solution of the Cauchy problem in terms of the ramified integrals obtained in Chapter 6 and describe the singularities of the solution. © Springer International Publishing AG 2017.
Savin A., Sternin B.
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Existence and uniqueness of solutions to singular ODE’s
Archiv der Mathematik, 2010 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Gorka, Przemyslaw, Rybka, Piotr
openaire +4 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Twin Solutions to Singular Dirichlet Problems
Journal of Mathematical Analysis and Applications, 1999 The authors consider the Dirichlet second-order boundary value problem \[ y''+ \phi(t)[g(y(t))+ h(y(t))]= 0,\quad 0< t< 1,\quad y(0)= y(1)= 0,\tag{1} \] and establish the existence of two solutions \(y_1,y_2\in C[0,1]\cap C^2(0, 1)\) with \(y_1> 0\), \(y_2> 0\) on \((0,1)\). The nonlinearity in (1) may be singular at \(y= 0\), \(t= 0\) and/or \(t= 1\).
Agarwal, R.P., O'Regan, D.
openaire +2 more sources