Results 21 to 30 of about 72,728 (266)

The second term of the asymptotics of the monodromy map in case of two even edges of the Newton diagram

Electronic Journal of Qualitative Theory of Differential Equations, 2000
The second term of the asymptotics of the monodromy map of monodromic singular point for some class of vector fields, Newton diagram of which consists of two even edges is computed; in that case the principal term of the asymptotics is an identity ...
N. Medvedeva, E. Batcheva
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

USING THE METHODS OF WAVELET ANALYSIS AND SINGULAR SPECTRUM ANALYSIS IN THE STUDY OF RADIO SOURCE BL LAC

Odessa Astronomical Publications, 2014
We investigated the monitoring data of extragalactic source BL Lac. This monitoring was held withUniversityofMichigan26-meter radio  telescope. To study flux density of extragalactic source BL Lac at frequencies of 14.5, 8 and 4.8 GHz, the wavelet ...
G. I. Donskykh, M. I. Ryabov, A. I. Sukharev, M. Aller   +3 more
doaj   +1 more source

Existence of positive solutions for singular p-Laplacian Hadamard fractional differential equations with the derivative term contained in the nonlinear term

Nonlinear Analysis, 2023
In this paper, based on the properties of Green function and the eigenvalue of a corresponding linear operator, the existence of positive solutions is investigated by spectral analysis for a infinite-points singular p-Laplacian Hadamard fractional ...
Limin Guo, Haimei Liu, Cheng Li, Jingbo Zhao, Jiafa Xu   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Frequency-Aware SVD Decomposition and its Application to Color Magnification and Motion Denoising

IEEE Access, 2021
Videos are full of dynamic changes along both the spatial and temporal dimensions. Large, jerky short-term motions make it difficult to extract significant changes from videos such as subtle color changes and long-term motions occurring in time-lapse ...
Ibrahim Kajo, Nidal Kamel, Yassine Ruichek, Abdulrahman Al-Ahdal   +3 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

A comparison of intensities of singular stress field for bonded cylinder under tension and bending

Nihon Kikai Gakkai ronbunshu, 2016
In this paper, the stress field at the interface corner edge of a bonded cylinder under bending is discussed by comparing with that under tension. Asymptotic description of the stress field under the bending consists of the singular stress term and the ...
Tatsujiro MIYAZAKI, Nao-Aki NODA, Yoshikazu SANO   +2 more
doaj   +1 more source