Results 31 to 40 of about 76,645 (265)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Solvability of Singular Fractional-Order Differential Equations with a Perturbation Term

Axioms
In this article, we study singular fractional-order differential equations with a variable coefficient, namely the linear operator of the differential equation containing a linear term with a variable coefficient. The coefficient a(s) permits singularity
Linghan Kong, Yongqing Wang
doaj   +1 more source

A comparison of intensities of singular stress field for bonded cylinder under tension and bending

Nihon Kikai Gakkai ronbunshu, 2016
In this paper, the stress field at the interface corner edge of a bonded cylinder under bending is discussed by comparing with that under tension. Asymptotic description of the stress field under the bending consists of the singular stress term and the ...
Tatsujiro MIYAZAKI, Nao-Aki NODA, Yoshikazu SANO   +2 more
doaj   +1 more source

Positive solutions for a class of singular (p, q)-equations

Advances in Nonlinear Analysis, 2023
We consider a nonlinear singular Dirichlet problem driven by the (p,q)\left(p,q)-Laplacian and a reaction where the singular term u−η{u}^{-\eta } is multiplied by a strictly positive Carathéodory function f(z,u)f\left(z,u).
Leonardi Salvatore, Papageorgiou Nikolaos S.   +1 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

A Singular Tempered Sub-Diffusion Fractional Equation with Changing-Sign Perturbation

Axioms
In this paper, we establish some new results on the existence of positive solutions for a singular tempered sub-diffusion fractional equation involving a changing-sign perturbation and a lower-order sub-diffusion term of the unknown function.
Xinguang Zhang, Jingsong Chen, Lishuang Li, Yonghong Wu   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source