Results 51 to 60 of about 4,581,421 (248)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Existence and nonexistence of positive solutions of nonlinear elliptic equations involving singular term and convection term

Electronic Journal of Qualitative Theory of Differential Equations
This paper establishes the existence and nonexistence of positive solutions for a class of Dirichlet problems involving singular nonlinearities and gradient-dependent terms. The nonlinearities considered are subcritical in the Sobolev sense. Our approach
Anderson de Araujo, Hamilton Bueno, Kamila Madalena   +2 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

A Singular Tempered Sub-Diffusion Fractional Equation with Changing-Sign Perturbation

Axioms
In this paper, we establish some new results on the existence of positive solutions for a singular tempered sub-diffusion fractional equation involving a changing-sign perturbation and a lower-order sub-diffusion term of the unknown function.
Xinguang Zhang, Jingsong Chen, Lishuang Li, Yonghong Wu   +3 more
doaj   +1 more source

Multiple Positive Solutions of Singular Nonlinear Sturm-Liouville Problems with Carathéodory Perturbed Term

Journal of Applied Mathematics, 2012
By employing a well-known fixed point theorem, we establish the existence of multiple positive solutions for the following fourth-order singular differential equation Lu=p(t)f(t,u(t),u′′(t))-g(t,u(t),u′′(t ...
Yuefeng Han, Xinguang Zhang, Lishan Liu, Yonghong Wu   +3 more
doaj   +1 more source

Positive Solutions for a Weakly Singular Hadamard-Type Fractional Differential Equation with Changing-Sign Nonlinearity

Journal of Function Spaces, 2020
In this paper, we focus on the existence of positive solutions for a class of weakly singular Hadamard-type fractional mixed periodic boundary value problems with a changing-sign singular perturbation.
Xinguang Zhang, Lixin Yu, Jiqiang Jiang, Yonghong Wu, Yujun Cui   +4 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Implementation of Higher-Order Two-Dimensional Singular Elements in FEM codes and Numerical Results problems [PDF]

, 2003
This paper presents strategies and schemes to implement higher-order two dimensional singular elements in Finite Elements codes.
Lombardi, Guido
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source