Results 31 to 40 of about 72,728 (266)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Positive solutions for a class of singular (p, q)-equations

Advances in Nonlinear Analysis, 2023
We consider a nonlinear singular Dirichlet problem driven by the (p,q)\left(p,q)-Laplacian and a reaction where the singular term u−η{u}^{-\eta } is multiplied by a strictly positive Carathéodory function f(z,u)f\left(z,u).
Leonardi Salvatore, Papageorgiou Nikolaos S.   +1 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Solvability of Singular Fractional-Order Differential Equations with a Perturbation Term

Axioms
In this article, we study singular fractional-order differential equations with a variable coefficient, namely the linear operator of the differential equation containing a linear term with a variable coefficient. The coefficient a(s) permits singularity
Linghan Kong, Yongqing Wang
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

A Singular Tempered Sub-Diffusion Fractional Equation with Changing-Sign Perturbation

Axioms
In this paper, we establish some new results on the existence of positive solutions for a singular tempered sub-diffusion fractional equation involving a changing-sign perturbation and a lower-order sub-diffusion term of the unknown function.
Xinguang Zhang, Jingsong Chen, Lishuang Li, Yonghong Wu   +3 more
doaj   +1 more source

Positive Solutions for a Weakly Singular Hadamard-Type Fractional Differential Equation with Changing-Sign Nonlinearity

Journal of Function Spaces, 2020
In this paper, we focus on the existence of positive solutions for a class of weakly singular Hadamard-type fractional mixed periodic boundary value problems with a changing-sign singular perturbation.
Xinguang Zhang, Lixin Yu, Jiqiang Jiang, Yonghong Wu, Yujun Cui   +4 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Existence and nonexistence of positive solutions of nonlinear elliptic equations involving singular term and convection term

Electronic Journal of Qualitative Theory of Differential Equations
This paper establishes the existence and nonexistence of positive solutions for a class of Dirichlet problems involving singular nonlinearities and gradient-dependent terms. The nonlinearities considered are subcritical in the Sobolev sense. Our approach
Anderson de Araujo, Hamilton Bueno, Kamila Madalena   +2 more
doaj   +1 more source