Results 51 to 60 of about 72,728 (266)

Elliptic perturbations for Hammerstein equations with singular nonlinear term

Electronic Journal of Differential Equations, 2006
We consider a singular elliptic perturbation of a Hammerstein integral equation with singular nonlinear term at the origin. The compactness of the solutions to the perturbed problem and, hence, the existence of a positive solution for the ...
Giuseppe Maria Coclite, Mario Michele Coclite   +1 more
doaj  

Positive Solutions for Second-Order Singular Semipositone Differential Equations Involving Stieltjes Integral Conditions

Abstract and Applied Analysis, 2012
By means of the fixed point theory in cones, we investigate the existence of positive solutions for the following second-order singular differential equations with a negatively perturbed term: −u′′(t)=λ[f(t,u(t))−q(t ...
Jiqiang Jiang, Lishan Liu, Yonghong Wu
doaj   +1 more source

Pointwise Gradient Estimates in Multi-dimensional Slow Diffusion Equations with a Singular Quenching Term

Advanced Nonlinear Studies, 2020
We consider the high-dimensional equation ∂t⁡u-Δ⁢um+u-β⁢χ{u>0}=0{\partial_{t}u-\Delta u^{m}+u^{-\beta}{\chi_{\{u>0\}}}=0}, extending the mathematical treatment made in 1992 by B. Kawohl and R. Kersner for the one-dimensional case.
Dao Nguyen Anh, Díaz Jesus Ildefonso, Nguyen Quan Ba Hong   +2 more
doaj   +1 more source

Nonexistence of solutions for the quasilinear parabolic differential inequalities with singular potential term and nonlocal source

Journal of Inequalities and Applications, 2020
This paper is devoted to proving some new nonexistence theorems for a class of quasilinear parabolic differential inequalities with a singular potential term and nonlocal source term in the case of homogeneous and non-homogeneous by the test function ...
Suping Xiao, Zhong Bo Fang
doaj   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Multiple solutions to a singular Lane-Emden-Fowler equation with convection term

Electronic Journal of Differential Equations, 2008
This article concerns the existence of multiple solutions for the problem $$displaylines{ -Delta u = K(x)u^{-alpha}+s(mathcal{A}u^eta+mathcal{B} | abla u|^zeta)+f(x) quad hbox{in }Omegacr u > 0 quad hbox{in }Omegacr u = 0 quad ...
Enrique Lami Dozo, Carlos C. Aranda
doaj  

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas, Mauro Monforte, Angel Sanchez‐Montañez, Penélope Romero‐Duque, Elena Pegoraro, Jordi Díaz‐Manera, Dmitry Vlodavets, Lorenzo Maggi, Marco Moscatelli, Adele D‘Amico, Montse Olivé, Jorge Alonso‐Pérez, Giacomo Comi, José Miguel Escudero‐Fernández, Gabriela S. Urcuyo, Anna Pichiecchio, Angela Berardinelli, Kristl G. Claeys, Claudio Bruno, Chiara Panicucci, Sara Bortolani, Eleonora Torchia, Enzo Ricci, Soledad Monges, Jorge A. Bevilacqua, Jorge Diaz‐Jara, Maggie C. Walter, Simone Thiele, Nicoline Løkken, John Vissing, Susana Quijano‐Roy, Robert Y. Carlier, Nicol C. Voermans, Chiara Marini‐Bettolo, Michela Guglieri, Volker Straub, Lea Leonardis, Francina Munell, David Gómez‐Andrés, Giorgio Tasca   +39 more
wiley   +1 more source