Results 21 to 30 of about 80,960 (263)

Singular limits solution for 2-dimensional elliptic problems involving exponential nonlinearities with sub-quadratic convection nonlinear gradient terms and singular weights

Advances in Nonlinear Analysis, 2014
Given a bounded open regular set Ω of ℝ2$\mathbb {R}^2$, q1,...,qK∈Ω${q_1, \ldots , q_K \hspace*{-0.85358pt}\in \hspace*{-0.85358pt} \Omega }$, a regular bounded function ϱ:Ω→[0,+∞)${\varrho \hspace*{-0.56905pt}:\hspace*{-0.56905pt} \Omega \hspace*{-0 ...
Baraket Sami, Ouni Taieb
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Inferential Rationality and Internalistic Scarecrows

Manuscrito
In a recent paper, Manuel Pérez Otero attempted to turn the tables on Paul Boghossian's claim that content externalism is incompatible with the 'a priority of our logical abilities'.
Paulo Faria
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Boundary value problems associated with singular strongly nonlinear equations with functional terms

Advances in Nonlinear Analysis, 2020
We study boundary value problems associated with singular, strongly nonlinear differential equations with functional terms of ...
Biagi Stefano, Calamai Alessandro, Marcelli Cristina, Papalini Francesca   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Sign-Changing Solutions for a Fourth-Order Elliptic Equation with Hardy Singular Terms

Journal of Applied Mathematics, 2013
The existence and multiplicity of sign-changing solutions for a class of fourth elliptic equations with Hardy singular terms are established by using the minimax methods.
Ruichang Pei, Jihui Zhang
doaj   +1 more source

Combining experimental and numerical analysis to estimate stress fields along the surface crack front [PDF]

Fracture and Structural Integrity, 2013
Combining experimental and computational method for determination of the singular and the non-singular stress terms along the front of the 3D surface crack is proposed.
A.S. Chernyatin, Yu.G. Matvienko, I.A. Razumovsky   +2 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source