Results 71 to 80 of about 914,727 (265)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

A Note on Inclusion Intervals of Matrix Singular Values

open access: yesJournal of Applied Mathematics, 2012
We establish an inclusion relation between two known inclusion intervals of matrix singular values in some special case. In addition, based on the use of positive scale vectors, a known inclusion interval of matrix singular values is also improved.
Shu-Yu Cui, Gui-Xian Tian
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

open access: yesFEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig   +7 more
wiley   +1 more source

svt: Singular Value Thresholding in MATLAB

open access: yesJournal of Statistical Software, 2017
Many statistical learning methods such as matrix completion, matrix regression, and multiple response regression estimate a matrix of parameters. The nuclear norm regularization is frequently employed to achieve shrinkage and low rank solutions.
Cai Li, Hua Zhou
doaj   +1 more source

Beyond singular values and loop shapes [PDF]

open access: yes
The status of singular value loop-shaping as a design paradigm for multivariable feedback systems is reviewed. It shows that this paradigm is an effective design tool whenever the problem specifications are spacially round.
Stein, G.
core   +1 more source

Sustainable bioplastics manufacturing from renewable sources

open access: yesFEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto   +6 more
wiley   +1 more source

On the singular values decoupling in the Singular Spectrum Analysis of volcanic tremor at Stromboli [PDF]

open access: yesNatural Hazards and Earth System Sciences, 2006
The well known strombolian activity at Stromboli volcano is occasionally interrupted by rarer episodes of paroxysmal activity which can lead to considerable hazard for Stromboli inhabitants and tourists. On 5 April 2003 a powerful explosion, which can be
R. Carniel   +3 more
doaj  

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