Results 61 to 70 of about 917,126 (263)

On the Structure of Advective Accretion Disks At High Luminosity

, 2000
Global solutions of optically thick advective accretion disks around black holes are constructed. The solutions are obtained by solving numerically a set of ordinary differential equations corresponding to a steady axisymmetric geometrically thin disk ...
Fukue J., Gennadi S. Bisnovatyi‐Kogan, Hshi R., Igor D. Novikov, Igor V. Igumenshchev, Ioulia V. Artemova, Matsumoto R., Muchotrzeb B., Muchotrzeb B., Muchotrzeb-Czerny B., Paczynski B., Paczynski B., Pringle J. E., Shakura N. I., Shakura N. I.   +14 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Computing Structured Singular Values for Sturm-Liouville Problems

International Journal of Analysis and Applications, 2019
In this article we present numerical computation of pseudo-spectra and the bounds of Structured Singular Values (SSV) for a family of matrices obtained while considering matrix representation of SturmLiouville (S-L) problems with eigenparameter-dependent
Mutti-Ur Rehman, Ghulam Abbas, Arshad Mehmood   +2 more
doaj   +2 more sources

Singular Values, Nematic Disclinations, and Emergent Biaxiality

, 2013
Both uniaxial and biaxial nematic liquid crystals are defined by orientational ordering of their building blocks. While uniaxial nematics only orient the long molecular axis, biaxial order implies local order along three axes.
Dennis, Mark R., Kamien, Randall D., Čopar, Simon, Žumer, Slobodan   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A quadratically convergent algorithm for inverse singular value problems with multiple singular values

Results in Applied Mathematics
In 2021, for inverse singular value problems, a quadratically convergent algorithm (Wei and Chen, 2021) based on matrix multiplication (Ogita and Aishima, 2020) was designed for inverse singular value problems. Although this method has some good features
Wei Ma, Yuqing Zhu
doaj   +1 more source

Rank-one perturbation bounds for singular values of arbitrary matrices

Journal of Inequalities and Applications, 2019
Rank-one perturbation of arbitrary matrices has many practical applications. In this paper, based on the relationship between the singular values and the eigenvalues, we discuss singular value variations and present two-side bounds of the singular values
Lei Zhu, Xiaofei Peng, Hao Liu
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source