Results 91 to 100 of about 23,701 (249)

The Singular World of Singular Cardinals [PDF]

open access: yes, 2015
To appear in Logic Without Borders: Essays on Set Theory, Model Theory, Philosophical Logic and Philosophy of Mathematics Edited by \AA sa Hirvonen, Juha Kontinen, Roman Kossak and Andr\'es ...
openaire   +4 more sources

Sudden future singularities [PDF]

open access: yesClassical and Quantum Gravity, 2004
We show that a singularity can occur at a finite future time in an expanding Friedmann universe even when the density is positive and the density plus the sum of the principal pressures is positive. Explicit examples are constructed and a simple condition is given which can be used to eliminate behaviour of this sort if it is judged to be unphysical.
openaire   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Flows, transits and (dis)connection points: contributions towards a critical Lusophony

open access: yesComunicação e Sociedade, 2018
As a concept, Lusophony is today looked upon with justified suspicion by many Portuguese-speaking people. It is impossible to separate this concept from the colonial ballast that bounds the countries that have Portuguese as the official language. However,
Luís Cunha   +2 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Singular Reference Without Singular Thought [PDF]

open access: yesManuscrito, 2016
Abstract In this paper I challenge the widespread assumption that the conditions for singular reference are more or less the same as the conditions for singular thought. I claim that we refer singularly to things without thinking singularly about them more often than it is usually believed.
openaire   +4 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Trans-Belief: Developing Artificial Intelligence NLP Model Capable of Religious-Belief-like Cognitive Processes for Expected Enhanced Cognitive Ability

open access: yesReligions
This paper investigates the possibility of developing artificial intelligence (AI) systems capable of exhibiting limited cognitive processes analogous to aspects of human religious belief.
Ido Dagan
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

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