Results 131 to 140 of about 581,282 (341)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Avionic Air Data Sensors Fault Detection and Isolation by means of Singular Perturbation and Geometric Approach [PDF]

, 2017
Paolo Castaldi, Nicola Mimmo, Silvio Simani   +2 more
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

ON SINGULARITIES OF QUIVER MODULI [PDF]

, 2010
M. Domokos
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Milnor Number and Chern Classes for Singular Varieties: An Introduction

, 2022
R. Callejas-Bedregal, M. F. Z. Morgado, José Seade   +2 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

The Singularity Is Near: When Humans Transcend Biology

, 2006
Raymond C. Kurzweil
semanticscholar   +2 more sources

Singularity Analysis of Lightlike Hypersurfaces Generated by Null Cartan Curves in Minkowski Spacetime

Axioms
This study investigates the singularity structures of lightlike hypersurfaces generated by null Cartan curves in Minkowski spacetime. We construct a hierarchical geometric framework consisting of a lightlike hypersurface LHβ, a critical lightlike surface
Xiaoming Fan, Yongsheng Zhu, Haijing Pan
doaj   +1 more source

Level-spacing distribution of a singular billiard [PDF]

, 1993
Takaomi Shigehara, N. Yoshinaga, Taksu Cheon, T. Mizusaki   +3 more
openalex   +1 more source