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STRUCTURE-FUNCTION RELATIONSHIPS OF THE SINOATRIAL NODE
International Journal of Bifurcation and Chaos, 2003The sinoatrial node, the pacemaker of the heart, is a structurally and functionally complex and heterogeneous structure. Histology, immunohistochemistry, electrophysiology and mathematical modeling of the sinoatrial node are reviewed to reveal the structure-function relationships of the sinoatrial node. It is argued that contact between the sinoatrial
Halina Dobrzynski +4 more
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Journal of Molecular and Cellular Cardiology, 1985
The primary pacemaker, i.e. the group of pacemaker cells discharging the sinoatrial node comprises less than 1000 cells in the guinea-pig and about 5000 cells in the rabbit. These primary pacemaker cells are described as 'central nodal' cells in light microscopy and as 'typical nodal' cells in electron microscopy.
T, Opthof +6 more
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The primary pacemaker, i.e. the group of pacemaker cells discharging the sinoatrial node comprises less than 1000 cells in the guinea-pig and about 5000 cells in the rabbit. These primary pacemaker cells are described as 'central nodal' cells in light microscopy and as 'typical nodal' cells in electron microscopy.
T, Opthof +6 more
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Functional morphology of the pig sinoatrial node
Journal of Molecular and Cellular Cardiology, 1987The porcine sinoatrial node in an isolated right atrium preparation is characterized by unifocal impulse generation. It has a rather elongated shape and the larger part of its volume is taken up by collagen and fibroblasts. The impulse appears to emerge from a site where the percentage of myofilaments is relatively low. The impulse is propagated faster
T, Opthof +3 more
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The Development of the Sinoatrial Node
1978In contrast to the many investigations devoted to the morphological development of the atrioventricular specialized tissues (see James, 1970; Anderson and Taylor, 1972 for review) few researchers have studied the development of the sinoatrial node. Amongst the reports existing on this subject, descriptions of the initial histological differentiation of
Robert H. Anderson +3 more
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Parasympathetic postganglionic pathways to the sinoatrial node
American Journal of Physiology-Heart and Circulatory Physiology, 1990Vagal ganglia that innervate the canine sinoatrial node (SAN) have been localized to a fat pad overlying and surrounding the right pulmonary vein complex (PVFP). The ventral epicardial surface of the right atrium was mapped in seven dogs anesthetized with alpha-chloralose after beta-blockade (timolol) and cardiac sympathetic and parasympathetic ...
K M, Bluemel +4 more
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The pacemaker cell of the sinoatrial node of the rabbit
American Journal of Physiology-Heart and Circulatory Physiology, 1978Rabbit sinoatrial nodes were isolated and studied in an attempt to determine the cell of origin of the true pacemaker potential. Cells of the sinoatrial node of the rabbit giving rise to the characteristic true pacemaker potential were iontophoretically tagged with lanthanum.
J J, Taylor, L S, D'Agrosa, E M, Burns
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Histamine and pacemaker shift in the sinoatrial node
Agents and Actions, 1994We used the isolated superfused preparations of right atrium with the zone of the sinoatrial node of rabbits to study the effects of histamine on the location of the dominant pacemaker. The preparations were cut into four pieces and electrical activity was recorded in each fragment by means of a surface suction electrode with internal KCl perfusion ...
E, Kevelaitis +2 more
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1976
The impulse for the activation of the heart is generated normally in the sinoatrial node (SA node). This structure covers an area of only a few square millimeters. The cells have an irregular contour and are small (diameter less than 10 μ). Furthermore, they contain sparse myofilaments which are often not well organized. The intercellular junctions are
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The impulse for the activation of the heart is generated normally in the sinoatrial node (SA node). This structure covers an area of only a few square millimeters. The cells have an irregular contour and are small (diameter less than 10 μ). Furthermore, they contain sparse myofilaments which are often not well organized. The intercellular junctions are
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If and sinoatrial node pacemaking
2004The majority of Na+ channels in the heart are composed of the tetrodotoxin (TTX)-resistant (KD, 2-6 μM) Nav1.5 isoform; however, recently it has been shown that TTX-sensitive (KD, 1-10 nM) neuronal Na+ channel isoforms (Nav1.1, Nav1.3 and Nav1.6) are also present and functionally important in the myocytes of the ventricles and the sinoatrial (SA) node.
A. Bucchi, M. Baruscotti, D. DiFrancesco
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