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Profiling Reduced Expression of Contractile and Mitochondrial mRNAs in the Human Sinoatrial Node vs. Right Atrium and Predicting Their Suppressed Expression by Transcription Factors and/or microRNAs. [PDF]
Int J Mol SciChen W +10 more
europepmc +1 more source
Pharmacologic Approach to Sinoatrial Node Dysfunction
Annual Review of Pharmacology and Toxicology, 2021 The spontaneous activity of the sinoatrial node initiates the heartbeat. Sino-atrial node dysfunction (SND) and sick sinoatrial (sick sinus) syndrome are caused by the heart's inability to generate a normal sinoatrial node action potential. In clinical practice, SND is generally considered an age-related pathology, secondary to degenerative fibrosis ...
Isabelle Bidaud +2 more
exaly +6 more sources
Molecular Pathway for the Localized Formation of the Sinoatrial Node [PDF]
Circulation Research, 2007 The sinoatrial node, which resides at the junction of the right atrium and the superior caval vein, contains specialized myocardial cells that initiate the heart beat. Despite this fundamental role in heart function, the embryonic origin and mechanisms of localized formation of the sinoatrial node have not been defined.
Willem Hoogaars +2 more
exaly +5 more sources
Journal of Molecular and Cellular Cardiology, 1985 The primary pacemaker, i.e. the group of pacemaker cells discharging the sinoatrial node comprises less than 1000 cells in the guinea-pig and about 5000 cells in the rabbit. These primary pacemaker cells are described as 'central nodal' cells in light microscopy and as 'typical nodal' cells in electron microscopy.
Habo J Jongsma +2 more
exaly +4 more sources
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Cardiac pacemaking in the sinoatrial node
Physiological Reviews, 1993Major topics addressed in this review on cardiac pacemaking in the sinoatrial node are; 1) isolated pacemaker cells; 2) membrane currents of sinoatrial node cells; 3) mechanism of pacemaking; 4) regulation of pacemaker ...
H, Irisawa, H F, Brown, W, Giles
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Connexins in the Sinoatrial and Atrioventricular Nodes
2006The sinoatrial node (SAN) and the atrioventricular node (AVN) are specialized tissues in the heart: the SAN is specialized for pacemaking (it is the pacemaker of the heart), whereas the AVN is specialized for slow conduction of the action potential (to introduce a delay between atrial and ventricular activation during the cardiac cycle).
Boyett, M. R. +12 more
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The surgical anatomy of the sinoatrial node
Surgical and Radiologic Anatomy, 1991The sinoatrial nodes (SAN) were observed, dissected, and measured on 95 adults and 30 child hearts under a dissection microscope. The majority of the SANs in adults are characterized by their pale color, firm consistency, and the location in relation to the penetration of the SAN artery, and they can be located in the superior part of the terminal ...
B M, He, Y X, Tan, M, Cheng, Y Q, Cui
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Reconstruction of the human sinoatrial node
The Anatomical Record, 1967AbstractThe superior vena cava and adjacent right atrium containing the sinoatrial node in each of five human hearts was studied histologically in serial section. The tissue block of a 41 year old man was reconstructed in four colors to provide a three‐dimensional model of the sinoatrial node, atrial relations, blood supply and nodal configuration. The
R C, Truex, M Q, Smythe, M J, Taylor
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Cardiovascular Drugs and Therapy, 1988
The sinoatrial node (SAN) was discovered in 1906 by Keith and Flack. The relation between its ultrastructure and function was first studied by Trautwein and Uchizono in 1963, whereas this relation was definitely established by Taylor and coworkers in 1978. The impulse originates from cells with a relatively low percentage of myofilaments.
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The sinoatrial node (SAN) was discovered in 1906 by Keith and Flack. The relation between its ultrastructure and function was first studied by Trautwein and Uchizono in 1963, whereas this relation was definitely established by Taylor and coworkers in 1978. The impulse originates from cells with a relatively low percentage of myofilaments.
openaire +2 more sources
STRUCTURE-FUNCTION RELATIONSHIPS OF THE SINOATRIAL NODE
International Journal of Bifurcation and Chaos, 2003The sinoatrial node, the pacemaker of the heart, is a structurally and functionally complex and heterogeneous structure. Histology, immunohistochemistry, electrophysiology and mathematical modeling of the sinoatrial node are reviewed to reveal the structure-function relationships of the sinoatrial node. It is argued that contact between the sinoatrial
Halina Dobrzynski +4 more
openaire +1 more source