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The Development of the Sinoatrial Node
1978In contrast to the many investigations devoted to the morphological development of the atrioventricular specialized tissues (see James, 1970; Anderson and Taylor, 1972 for review) few researchers have studied the development of the sinoatrial node. Amongst the reports existing on this subject, descriptions of the initial histological differentiation of
Ho Siew Yen+3 more
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Journal of Molecular and Cellular Cardiology, 1985
The primary pacemaker, i.e. the group of pacemaker cells discharging the sinoatrial node comprises less than 1000 cells in the guinea-pig and about 5000 cells in the rabbit. These primary pacemaker cells are described as 'central nodal' cells in light microscopy and as 'typical nodal' cells in electron microscopy.
M. Masson-Pévet+6 more
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The primary pacemaker, i.e. the group of pacemaker cells discharging the sinoatrial node comprises less than 1000 cells in the guinea-pig and about 5000 cells in the rabbit. These primary pacemaker cells are described as 'central nodal' cells in light microscopy and as 'typical nodal' cells in electron microscopy.
M. Masson-Pévet+6 more
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Parasympathetic postganglionic pathways to the sinoatrial node
American Journal of Physiology-Heart and Circulatory Physiology, 1990Vagal ganglia that innervate the canine sinoatrial node (SAN) have been localized to a fat pad overlying and surrounding the right pulmonary vein complex (PVFP). The ventral epicardial surface of the right atrium was mapped in seven dogs anesthetized with alpha-chloralose after beta-blockade (timolol) and cardiac sympathetic and parasympathetic ...
R. D. Wurster+4 more
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MDCT of the S-Shaped Sinoatrial Node Artery
American Journal of Roentgenology, 2008The purpose of this study was to use 64-MDCT to investigate the anatomic characteristics of the S-shaped variant of the sinoatrial node (SAN) artery and to describe the clinical implications of the findings in ablative procedures involving the left atrium.Coronary CT angiograms of 250 patients (152 men, 98 women; mean age, 60 +/- 12 [SD] years) were ...
Stephanie Channual+5 more
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1976
The impulse for the activation of the heart is generated normally in the sinoatrial node (SA node). This structure covers an area of only a few square millimeters. The cells have an irregular contour and are small (diameter less than 10 μ). Furthermore, they contain sparse myofilaments which are often not well organized. The intercellular junctions are
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The impulse for the activation of the heart is generated normally in the sinoatrial node (SA node). This structure covers an area of only a few square millimeters. The cells have an irregular contour and are small (diameter less than 10 μ). Furthermore, they contain sparse myofilaments which are often not well organized. The intercellular junctions are
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The pacemaker cell of the sinoatrial node of the rabbit
American Journal of Physiology-Heart and Circulatory Physiology, 1978Rabbit sinoatrial nodes were isolated and studied in an attempt to determine the cell of origin of the true pacemaker potential. Cells of the sinoatrial node of the rabbit giving rise to the characteristic true pacemaker potential were iontophoretically tagged with lanthanum.
L. S. D'Agrosa+2 more
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Histamine and pacemaker shift in the sinoatrial node
Agents and Actions, 1994We used the isolated superfused preparations of right atrium with the zone of the sinoatrial node of rabbits to study the effects of histamine on the location of the dominant pacemaker. The preparations were cut into four pieces and electrical activity was recorded in each fragment by means of a surface suction electrode with internal KCl perfusion ...
E. Kevelaitis+2 more
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Rhythmogenesis in the heart sinoatrial node
Biophysics, 2006The most significant experimental data on the formation of the common rhythm of the heart sinoatrial node are presented for both the intact heart sinoatrial node and cardiomyocytes in cell structures. The basic mathematical models for studying the synchronization processes in the sinoatrial node, including the Noble equation, Bonhoffer-van der Pol ...
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Inward current of the rabbit sinoatrial node cell
Pfl�gers Archiv European Journal of Physiology, 1977Inward currents of the rabbit sinoatrial node cell were examined in voltage-clamp experiments using the two-microelectrode technique. A fast and slow inward current could be separated from each other. The slow inward current was blocked by Mn and D 600, but it was insensitive to TTX.
K Yanagihara+2 more
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A gradient model of the rabbit sinoatrial node
Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439), 2004We have formulated a gradient model of the rabbit sinoatrial node based on cell-specific ionic models of electrical activity from its central and peripheral regions. The gradient model exhibits a smooth transition in action potential characteristics such as maximum diastolic potential, overshoot potential, upstroke velocity, action potential duration ...
Socrates Dokos+2 more
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