Results 81 to 90 of about 36,244 (312)

Dual Physiological Barriers Bypassed by a Silk‐Based Supramolecular Protein Delivery Platform for Neuroinflammation Mitigation in Alzheimer's Disease

Advanced Science, EarlyView.
A supramolecular nanocomplex based on phenolic‐modified silk sericin is developed to deliver antioxidant enzymes across the blood–brain barrier and escape lysosomal degradation. This dual‐barrier‐crossing system reduces neuroinflammation and improves cognitive performance in Alzheimer's disease mouse model, offering a promising strategy for protein ...
Doudou Hu, Tiandong Li, Jian He, Yujian Jiang, Yeyuan Wang, Jingchen Sun   +5 more
wiley   +1 more source

Assessment of Some Immunological Parameters Postvaccination with Different Types of COVID-19 Vaccines

Medical Journal of Babylon
Background: Coronavirus disease 2019 (COVID-19) is a highly contagious viral infection that can spread rapidly worldwide. Several vaccines have been developed to combat COVID-19.
Haneen Saad Khasbak, Hayder Shkhair Al-Janabi, Mohanad Jawad Kadhim   +2 more
doaj   +1 more source

Simultaneous determination of five diuretic drugs using quantitative analysis of multiple components by a single marker

BMC Chemistry, 2021
Background Loop diuretics are commonly used in clinical practice to manage high fluid loads and to control fluid balance. In this paper, a novel quantitative analysis method for multiple components with a single marker (QAMS) was developed for the ...
Fuchao Chen, Baoxia Fang, Peng Li, Sicen Wang   +3 more
doaj   +1 more source

Adverse reactions of the Sinopharm and Pfizer vaccine in the population vaccinated against COVID 19 in Huancayo - 2021

, 2022
El objetivo del presente trabajo fue comparar las reacciones adversas de las vacunas de Sinopharm y Pfizer en la población vacunada contra el COVID 19 en Huancayo – 2021.
Chagua Esteban, Evelyn Vanessa, Vargas Antezana, Lilia   +1 more
core  

Analysis and comparison of anti-RBD neutralizing antibodies from AZD-1222, Sputnik V, Sinopharm and Covaxin vaccines and its relationship with gender among health care workers

, 2022
BACKGROUND: Vaccine efficiency has a significant role in the public perception of vaccination. The current study was designed to evaluate the efficacy of COVID-19 vaccines (AZD-1222, Sputnik-V, Sinopharm, and Covaxin) and the effect of gender on vaccine ...
Royce, Simon G, Mahmoudzadeh, Sara, Fereidouni, A, Rezapour, Hadis, Fereidouni, Mohammad, Nikpour, S, Rezapour, H, Nikpour, Saboura, Mahmoudzadeh, S, Fereidouni, M, Zare, H, Fereidouni, Alireza, Royce, SG, Zare, Hamed   +13 more
core   +1 more source

A Crack‐Based One‐Dimensional Microspheres Array Enables Thermal–Mechanical Decoupled Dual‐Functional Sensing

Advanced Science, EarlyView.
Inspired by Nostoc, a crack‐based one‐dimensional microspheres array (COMA) sensor is developed, which stabilizes crack geometry under isotropic expansion, enabling a predictable, monotonic thermal response from which true strain can be accurately extracted. The COMA sensor exhibits high sensitivity at ultralow deformation (gauge factor up to 89) and a
Wanqing Xu, Hongyi Tu, Zehao Wang, Tianyu Zhu, Chao Wang, Min Chen, Lan Shi, Limin Wu   +7 more
wiley   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

Feasibility of preparing human plasminogen by full chromatography from precipitation of Fraction Ⅲ in low temperature ethanol method

Zhongguo shuxue zazhi
[Objective] To determine the feasibility of preparing plasminogen (Pg) with Fraction Ⅲ precipitation (hereinafter referred to as FⅢ-P) from low-temperature ethanol process by full chromatography (hereinafter referred to as FⅢ-P process). [Methods] The FⅢ-
ZHANG Jin, YUE Shenglan, ZHU Chen, PENG Yan, ZHOU Yanxiang, LIN Lianzhen, CHEN Kejin, FENG Lu, HU Yong, ZHOU Zhijun   +9 more
doaj   +1 more source

Dual‐Stage Microneedle Patch With Lipid Droplet‐Mediated ‘Capture‐Kill’ and Sustained Release for Enhanced Wound Healing

Advanced Science, EarlyView.
We report a lipid‐droplet‐engineered, gallium‐loaded sonodynamic therapeutic platform (LDTG) incorporated into a bilayer microneedle (MN) patch co‐delivering all‐trans retinoic acid (ATRA), termed LDTG A‐MNs, for synergistic antibacterial therapy and accelerated wound repair.
Peng Jiang, Meijun Jiang, Jiapeng Lei, Wen Zhang, Huiyuan Yang, Xueyang Wang, Siyu Zhang, Qiongfang Ruan, Shuhua Liu, Wei Li   +9 more
wiley   +1 more source

Prevalence of the COVID-19 vaccines adverse effects (percentage) associated with various vaccine types (Pfizer, AstraZeneca and Sinopharm) among vaccinated participants.

, 2022
(A) after the first dose, (B) after the second dose. A statistical analysis of the adverse effects associated with various COVID-19 vaccines (Pfizer versus AstraZeneca, Pfizer versus Sinopharm, AstraZeneca versus Sinopharm) was performed using the chi ...
Naif Al-Jomah (9118583), Tola Faraj (14141838), Muath Ameen (14141844), Mohammed Alswes (14141850), Nasir Khatab (14141832), Azad Kamal-Aldin (14141847), Omeed Darweesh (14141829), Ramiar Kheder (7781564), Thulfiqar Mohammed (14141835), Sabah Ali (14141841)   +9 more
core   +1 more source