Results 41 to 50 of about 1,829 (218)

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Humans are not unique: difficult birth is common in placental mammals

Biological Reviews, EarlyView.
ABSTRACT Human childbirth is widely presumed to be uniquely difficult and dangerous compared to birth in other mammals. Tight fetopelvic proportions can result in obstructed labour and contribute to high rates of maternal and neonatal mortality. Ideas summarised under the ‘obstetrical dilemma’ have contributed to this assumption by explaining difficult
Nicole D. S. Grunstra
wiley   +1 more source

Mammalian Diversity and Matses Ethnomammalogy in Amazonian Peru Part 2: Xenarthra, Carnivora, Perissodactyla, Artiodactyla, and Sirenia

, 2017
Voss, Robert S., Fleck, David W. (2017): Mammalian Diversity And Matses Ethnomammalogy In Amazonian Peru Part 2: Xenarthra, Carnivora, Perissodactyla, Artiodactyla, And Sirenia.
Voss, Robert S., Robert S. Voss, David W. Fleck, Fleck, David W.   +3 more
core   +1 more source

ON A SKULL OF A SIRENIAN FROM THE EARLY PLIOCENE OF SIENA, TUSCANY

Rivista Italiana di Paleontologia e Stratigrafia, 2020
A fine skull of a sirenian from Early Pliocene littoral sands with Late Ruscinian terrestrial mammals near Siena is referred to Metaxitherium gervaisi (Capellini, 1872); it provides detailed information on the characters of this species, which was ...
DANIELA CANOCCHI
doaj  

The small molecule simufilam dose‐dependently attenuates the worsening of seizures in a mouse model of tuberous sclerosis complex

Epilepsia, EarlyView.
Abstract Objective Novel epilepsy treatments for patients with tuberous sclerosis complex (TSC) and focal cortical dysplasia type II (FCDII) are urgently needed. In these patients, mutations in the mechanistic target of rapamycin (mTOR) pathway genes lead to mTOR hyperactivity and focal cortical malformations that frequently cause intractable epilepsy ...
Branden Stansley, Md. Monirul Islam, Dean J. Aguiar, Zoë Fuchs, Mackenzie Catron, Stephen Morairty, Ying Yuan, Radleigh Santos, Jingguo Hou, Annelies de Kater, George B. Thornton, Angelique Bordey   +11 more
wiley   +1 more source

Cannabidiol reduces atypical absence seizures and epileptic spasms in a Gabrb3+/D120N mouse model of Lennox–Gastaut syndrome

Epilepsia Open, EarlyView.
Abstract Objective Lennox–Gastaut syndrome (LGS) is a drug‐resistant developmental and epileptic encephalopathy (DEE). Preclinical drug development for LGS is constrained by a lack of syndrome‐relevant animal models. We aimed to evaluate a Gabrb3+/D120N knock‐in (KI) mouse model of LGS by quantifying atypical absence seizures and epileptic spasms and ...
Thomas Harman, Laura A. Sharman, Ka Lai Yip, Miguel Bedoya‐Pérez, Vaishali Janve, Jonathon C. Arnold   +5 more
wiley   +1 more source

FIG. 2 in New record of Metaxytherium (Mammalia, Sirenia) from the lower Miocene of Manosque (Provence, France)

, 2008
FIG. 2. — Skull of Meta­xytherium cf. kra­huletzi Depéret, 1895 (MP- NRL-MAN2000) from Manosque (Provence, France): A, left lateral view; B, posterior view; C, dorsal view.
Sorbi, Silvia
core   +1 more source

Kognitívny a evolučný kontext šírenia konšpirračných teórií [PDF]

Slovenský Národopis, 2015
The goal of this article is to provide a cognitive explanation of some aspects of conspiracy theories which influence their spread in society. One important human mental capacity is the ability to produce beliefs about mental states (intentions ...
Vladimír Bahna
doaj  

Diet composition of the African manatee: Spatial and temporal variation within the Sanaga River Watershed, Cameroon

Ecology and Evolution, 2021
The present study aimed to investigate the diet of African manatees in Cameroon to better inform conservation decisions within protected areas. A large knowledge gap on diet and seasonal changes in forage availability limits the ability to develop ...
Aristide Takoukam Kamla, Dylan G. E. Gomes, Cathy A. Beck, Lucy W. Keith‐Diagne, Margaret E. Hunter, Ruth Francis‐Floyd, Robert K. Bonde   +6 more
doaj   +1 more source

Cytochemical staining of leukocytes and platelets in the Florida manatee (Trichechus manatus latirostris): identification of a bilobed monocyte similar to other members of the Paenungulata

Frontiers in Veterinary Science, 2023
Manatees (Antillean-, Amazonian, and African-) and dugongs belong to the Order Sirenia, and when combined with elephants and rock hyraxes, form the Paenungulata. A bilobed mononuclear cell has previously been identified in elephants and rock hyraxes, but
Laura A. Cagle, Nicole I. Stacy, John W. Harvey, Martine de Wit, Laurie Adler, Michael Walsh, Robert Bonde, Tracy Stokol   +7 more
doaj   +1 more source