Results 51 to 60 of about 1,232 (176)

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, Volume 13, Issue 41, 22 July 2026.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

A new estimate of afrotherian phylogeny based on simultaneous analysis of genomic, morphological, and fossil evidence

BMC Evolutionary Biology, 2007
Background The placental mammalian clade Afrotheria is now supported by diverse forms of genomic data, but interordinal relationships within, and morphological support for, the group remains elusive.
Seiffert Erik R
doaj   +1 more source

The small molecule simufilam dose‐dependently attenuates the worsening of seizures in a mouse model of tuberous sclerosis complex

Epilepsia, Volume 67, Issue 7, Page 3753-3765, July 2026.
Abstract Objective Novel epilepsy treatments for patients with tuberous sclerosis complex (TSC) and focal cortical dysplasia type II (FCDII) are urgently needed. In these patients, mutations in the mechanistic target of rapamycin (mTOR) pathway genes lead to mTOR hyperactivity and focal cortical malformations that frequently cause intractable epilepsy ...
Branden Stansley, Md. Monirul Islam, Dean J. Aguiar, Zoë Fuchs, Mackenzie Catron, Stephen Morairty, Ying Yuan, Radleigh Santos, Jingguo Hou, Annelies de Kater, George B. Thornton, Angelique Bordey   +11 more
wiley   +1 more source

How to remove the brain of Amazonian manatee (Trichechus inunguis) calves preserving the skull for morphological analysis [PDF]

Acta Amazonica
Although there are several studies on the skull of Amazonian manatees (Trichechus inunguis) to better understand the anatomy, physiology, and behavior of these animals, the analysis of the brain has been often neglected.
Kamilla AVELINO-DE-SOUZA, Gisele de Castro Maciel VALDEVINO, Gabriel MELO-SANTOS, Bruno MOTA, Vera Maria Ferreira DA SILVA   +4 more
doaj   +1 more source

First Non‐Invasive Monitoring of Fecal Steroids in Greater Caribbean Manatees (Trichechus manatus manatus)

Zoo Biology, Volume 45, Issue 4, Page 435-443, July/August 2026.
This study established the first fecal hormonal reference values (P4/E2) for the Greater Caribbean manatee. Using non‐invasive ELISA, the authors found no significant differences between mature and immature females, highlighting that long‐term monitoring and ultrasounds are essential to fully understand their complex reproductive cycles.
Vanessa Bermúdez‐Cardona, Roberto Sánchez‐Okrucky, José A. Sandoval‐Zárate, Nataly Castelblanco‐Martínez   +3 more
wiley   +1 more source

Food Plants Eaten by Amazonian Manatees (Trichechus inunguis, Mammalia : Sirenia)

Brazilian Archives of Biology and Technology, 2002
To determine the feeding habits of the Amazonian manatee Trichechus inunguis in some Central Amazonian rivers and lakes, we compared plant epidermis found in the stomach contents and/or faeces of animals with a reference collection of plants present in ...
Ioni G. Colares, Elton P. Colares
doaj   +1 more source

Habitat Suitability for a Unique, Fully Marine American Manatee (Trichechus manatus) Population Primarily Depends on Presence of Submarine Freshwater Springs

Marine Mammal Science, Volume 42, Issue 3, July 2026.
ABSTRACT The American manatee (Trichechus manatus) requires freshwater mainly from rivers and springs to maintain osmoregulatory balance in saline environments. However, in Brazil's semi‐arid Potiguar Basin, manatees now rely solely on submarine freshwater springs because hypersaline estuaries have become unsuitable sources of freshwater.
A. C. O. Meirelles, I. C. Normande, M. D. O. Alves, K. F. Choi, V. L. Carvalho, J. C. G. Borges, L. von Fersen, Andrew W. Trites   +7 more
wiley   +1 more source

Morphology, morphometry and ultrastructure of the Amazonian manatee (Sirenia: Trichechidae) spermatozoa

Zoologia (Curitiba), 2010
This study describes the morphological, morphometric and ultrastructural characteristics of the Amazonian manatee Trichechus inunguis (Natterer, 1883) spermatozoon. The spermatozoa were obtained from a urine sample of an adult T.
Rodrigo S. Amaral, Carolina M. Lucci, Fernando C. W. Rosas, Vera M. F. da Silva, Sônia N. Báo   +4 more
doaj   +1 more source

Order Sirenia

, 1982
James H. Honacki, Kenneth E. Kinman, James W. Koeppl (1982): Order Sirenia. In: James H. Honacki, Kenneth E. Kinman, James W. Koeppl (Eds): Mammal Species of the World (1st Edition). Lawrence, Kansas, USA: Alien Press, Inc. & The Association of Systematics Collections: 305-306, ISBN: 0-89327-235-3, DOI: http://doi.org/10.5281/zenodo ...
James H. Honacki, Kenneth E. Kinman, James W. Koeppl   +2 more
openaire   +2 more sources

Early microglial response to amyloid plaques drives sleep loss in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Sleep disruption is an early feature of Alzheimer's disease (AD), but the cellular mechanisms linking amyloid pathology to sleep loss remain unclear. METHODS Electroencephalography/electromyography (EEG/EMG) recordings, quantitative EEG analysis, and sleep deprivation were performed in APPswe/PSEN1dE9 (APP/PS1) mice at different ...
Nicholas J. Constantino, Riley E. Irmen, Matthew J. Lanning, Sierra M. Turner, Clair C. Ashley, Caitlin M. Carroll, Evan M. Neary, Dave Rubinow, J. Andy Snipes, Shannon L. Macauley   +9 more
wiley   +1 more source