Results 101 to 110 of about 60,209 (283)

Quantification of Lateralized Overgrowth and Genotype‐Driven Tissue Composition

Clinical Genetics, EarlyView.
Lateralized overgrowth involves asymmetric body growth across conditions. TB‐DXA accurately identifies and quantifies tissue overgrowth, showing varied patterns among conditions and improving diagnosis. ABSTRACT Lateralized overgrowth (LO) is characterized by excessive growth of one side of the body compared to the other.
Andrea Gazzin, Giuseppe Reynolds, Damiano Allegro, Davide Rossi, Francesca Sciandra, Hirad Akberi Afkhami, Simona Cardaropoli, Marilidia Piglionica, Nicoletta Resta, Marco Di Stefano, Alessandro Mussa   +10 more
wiley   +1 more source

The patient perspective on sirolimus for epithelioid hemangioendothelioma (EHE): results of a community survey highlighting the importance of equitable access to treatments

Frontiers in Oncology
BackgroundEpithelioid hemangioendothelioma (EHE) is an ultra-rare, vascular sarcoma with clinical presentation ranging from an indolent to an aggressive form.
Denise Robinson, Hugh Leonard, Giacomo Giulio Baldi, William D. Tap, Robin L. Jones, Silvia Stacchiotti, Pan Pantziarka, Pan Pantziarka   +7 more
doaj   +1 more source

Production and Functional Verification of 8‐Gene (GGTA1, CMAH, β4GalNT2, hCD46, hCD55, hCD59, hTBM, hCD39)‐Edited Donor Pigs for Xenotransplantation

Cell Proliferation, EarlyView.
Schematic representation of generation of 8‐gene‐edited cloned pigs and their verification by pig to non‐human primate kidney xenotransplantation. ABSTRACT Gene‐edited (GE) pig‐to‐human xenotransplantation continues to make breakthroughs, but which kind of gene combination is suitable for organ‐specific transplantation remains unclear.
Jiaoxiang Wang, Kaixiang Xu, Tao Liu, Heng Zhao, Muhammad Ameen Jamal, Gen Chen, Xiaoying Huo, Chang Yang, Deling Jiao, Taiyun Wei, Hanfei Huang, Hongfang Zhao, Jianxiong Guo, Fengchong Wang, Xiong Zhang, Kai Liu, Siming Qu, Gang Wang, Hui Guo, Gang Chen, Hong‐Ye Zhao, Zhong Zeng, Kefeng Dou, Hong‐Jiang Wei   +23 more
wiley   +1 more source

Repurposing metformin for cancer treatment: current clinical studies. [PDF]

, 2016
In recent years, several studies have presented evidence suggesting a potential role for metformin in anti-cancer therapy. Preclinical studies have demonstrated several anticancer molecular mechanisms of metformin including mTOR inhibition, cytotoxic ...
Altman, Jessica K, Arya, Ayush, Carneiro, Benedito, Chae, Young Kwang, Chandra, Sunandana, Giles, Francis, Kalyan, Aparna, Kaplan, Jason, Malecek, Mary-Kate, Platanias, Leonidas, Shin, Daniel Sanghoon   +10 more
core   +1 more source

Facial angiofibromas of tuberous sclerosis treated with topical sirolimus in an Indian patient

Indian Journal of Dermatology, 2015
Facial angiofibromas are the most visible and unsightly of all the cutaneous manifestations of tuberous sclerosis (TSC). A 17-year-old female, a known case of TSC, presented for the treatment of cosmetically disfiguring facial angiofibromas.
Resham J Vasani
doaj   +1 more source

Quality of life associated with sirolimus for prevention of graft-versus-host disease: results from a randomized trial

Haematologica, 2014
Several studies have examined sirolimus-based immune suppression for the prevention of graft-versus-host disease after allogeneic hematopoietic cell transplantation, but little is known regarding its effects on quality of life.
Heather S.L. Jim, Anna Barata, Brent J. Small, Paul B. Jacobsen, Joseph Pidala   +4 more
doaj   +1 more source

Antilymphoid antibody preconditioning and tacrolimus monotherapy for pediatric kidney transplantation [PDF]

, 2006
Objective: Heavy post-transplant immunosuppression may contribute to long-term immunosuppression dependence by subverting tolerogenic mechanisms; thus, we sought to determine if this undesirable consequence could be mitigated by pretransplant lymphoid ...
Abhay N. Vats, Adrianna Zeevi, Akhtar S. Khan, Amadeo Marcos, Amit Basu, Bartosh, Calne, Calne, Chakrabarti, Corde McFeaters, Demetrius Ellis, Edward A. Gray, Fine, Gerri James, Halloran, Henkie P. Tan, Jensen, Kirk, Knechtle, Lilly, Mary Jo Grosso, McCurry, Michael L. Moritz, Mueller, Najarian, Nankivell, Purighalla, Randhawa, Reyes, Riley, Ron Shapiro, Sarwal, Shapiro, Shapiro, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Stuart, Thomas E. Starzl, Todo, Waldmann, Williams   +52 more
core   +1 more source

Impact of sirolimus on long‐term adverse cardiovascular outcomes in kidney transplant recipients: A nationwide cohort study

European Journal of Clinical Investigation, EarlyView.
The findings demonstrated no significant difference in MACE between the sirolimus‐treated and untreated groups (hazard ratio, 1.40; 95% confidence interval, .77–2.55), despite a higher incidence of dyslipidaemia in the sirolimus‐treated group. However, subgroup analysis indicated an increased MACE risk in KTRs with pre‐transplant congestive heart ...
Jinhyun Park, Wonhui Choi, Jinseub Hwang, Ha Young Jang, Yun Kim, Young‐Mi Ah, Jin‐Won Kwon, Kyung Hee Choi, Yun‐Kyoung Song   +8 more
wiley   +1 more source

Long-term efficacy and safety of sirolimus therapy in patients with lymphangioleiomyomatosis

Orphanet Journal of Rare Diseases, 2019
Background Sirolimus has been confirmed to be effective for lymphangioleiomyomatosis (LAM), a rare multisystem neoplastic disease in women. The long-term effects of sirolimus treatment for LAM, however, are largely unknown.
Siqi Hu, Xiuxiu Wu, Wenshuai Xu, Xinlun Tian, Yanli Yang, Shao-Ting Wang, Song Liu, Xingxiang Xu, Kai-Feng Xu   +8 more
doaj   +1 more source

Sirolimus approved with renal transplant indication [PDF]

, 1999
Jane L. Miller
openalex   +1 more source