Results 151 to 160 of about 68,914 (294)

Immune Reconstitution after Haploidentical Hematopoietic Stem Cell Transplantation with Different Non‐T‐Cell Depletion Protocols

MedComm, Volume 6, Issue 6, June 2025.
This review examines immune reconstitution dynamics after haploidentical hematopoietic stem cell transplantation using different non‐T‐cell depletion protocols, including the Beijing and Baltimore protocols. It summarizes the reconstitution patterns of immune cell subsets and their correlation with posttransplant complications like relapse, GVHD, and ...
Xiao‐Di Ma, Zheng‐Li Xu, Xiao‐Jun Huang   +2 more
wiley   +1 more source

SIROLIMUS EXACERBATES CsA-INDUCED NEPHROTOXICITY BY RAISING CsA BLOOD TROUGH LEVELS, BUT DOES NOT IMPAIR RENAL FUNCTION BY A PHARMACODYNAMIC INTERACTION

, 1999
Hemangshu Podder, Stanislaw M. Stepkowski, Kimberly L. Napoli, B D Kahan   +3 more
openalex   +1 more source

Validation of an Assay for Routine Monitoring of Sirolimus Using HPLC with Mass Spectrometric Detection [PDF]

, 2000
David W. Holt, Terry Lee, K Jones, A. E. Johnston   +3 more
openalex   +1 more source

Myeloid‐Derived Suppressor Cells in Cancer: Mechanistic Insights and Targeted Therapeutic Innovations

MedComm, Volume 6, Issue 6, June 2025.
This review summarizes the origin and biological characteristics of MDSCs, focusing on their immunological and nonimmunological roles in tumor progression. It also discusses the prognostic value of MDSCs and the latest advancements in clinical trials, highlighting the potential of emerging therapeutic strategies for cancer treatment and drug ...
Tianying Hu, Jianxue Zhai, Zhanda Yang, Jiajia Peng, Chuxuan Wang, Xinyao Liu, Yawen Li, Jiaqi Yao, Fengxi Chen, Haixia Li, Taixue An, Zongcai Liu, Haifang Wang   +12 more
wiley   +1 more source

Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD) [PDF]

, 2017
Background. Autosomal dominant polycystic kidney disease (ADPKD) is characterized by dysregulated tubular epithelial cell growth, resulting in the formation of multiple renal cysts and progressive renal failure.
Hall, Michael N., Le Hir, Michel, Molle, Klaus D., Serra, Andreas L., Wahl, Patricia R., Wüthrich, Rudolf P.   +5 more
core  

EFFECT OF SIROLIMUS ON PLASMA LIPID AND LIPOPROTEIN LEVELS AND METABOLISM IN RENAL TRANSPLANT PATIENTS

, 1999
Joel D. Morrisett, Christie M. Ballantyne, Henry J. Pownall, Antone R. Opekun, Jonathan S. Jaffe, Suzanne Oppermann, B D Kahan   +6 more
openalex   +1 more source

Resveratrol: Molecular Mechanisms, Health Benefits, and Potential Adverse Effects

MedComm, Volume 6, Issue 6, June 2025.
As a polyphenol substance with important potential, resveratrol has important potential in degenerative diseases, cardiovascular diseases, cancer, neurological diseases, etc. However, it is still necessary to pay attention to its bioavailability and potential adverse effects.
Zhuo‐qun Ren, Sheng‐yuan Zheng, Zhengcheng Sun, Yan Luo, Yu‐tong Wang, Ping Yi, Yu‐sheng Li, Cheng Huang, Wen‐feng Xiao   +8 more
wiley   +1 more source

Advancements in Magnesium Applications, Biocompatible Implants to Nanoparticles in Medicine and Biomedical Innovations

MetalMat, Volume 2, Issue 2, June 2025.
Magnesium (Mg) and its alloys are identified as prospective materials for orthopedic and cardiovascular applications because of their bio‐corrosiveness and ability to stimulate tissue reparative processes. Although compared with traditional metals, Mg is biocompatible; however, it has various problems that stem from its biodegradation nature, for ...
Muhammad Mubeen, Salman Khalid, Mohammad Tabish, Mubashar Mahmood, Muhammad Jawad, Muhammad Uzair Malik, Ghulam Yasin   +6 more
wiley   +1 more source

Role and Mechanisms of the mTOR Signalling Pathway in the Synthesis of Milk Components

Modern Agriculture, Volume 3, Issue 1, June 2025.
The regulatory network system of mTOR regulates lactose, milk fat, and milk protein. Milk is urgently needed for the strong development of the dairy industry to meet the growing demand and ensure that the nutritional needs of the world's population are met.
RongNuo Li, YiNing Zheng, HuiJun Geng, Lu Deng   +3 more
wiley   +1 more source

Sirolimus-induced pulmonary toxicity without recurrence more than 8 years after everolimus replacement in a renal transplant patient with recurrent skin SCC: a case report

BMC Nephrology
Background Interstitial Pneumonitis (IP) is one of the pulmonary complications associated with mammalian Target of Rapamycin-Inhibitors (mTOR-Is). Sirolimus and everolimus belong to mTOR-Is. According to studies, IP is caused by both.
Golsa Ghasemi, Shahrzad Shahidi
doaj   +1 more source