Results 51 to 60 of about 103,636 (276)

VDAC1‐Targeted NHK1 Peptide Recovers Mitochondrial Dysfunction Counteracting Amyloid‐β Oligomers Toxicity in Alzheimer's Disease

open access: yesAging Cell, Volume 24, Issue 7, July 2025.
Amyloid‐β (Aβ) oligomers affect VDAC1 electrophysiology and the physiological metabolic cross‐talk between cytosol and mitochondria. The use of a small, synthetic VDAC1‐antagonist peptide, derived from hexokinase, restores mitochondrial functionality, and respiration in cellular models of Alzheimer's disease. ABSTRACT Mitochondrial dysfunction has been
Fabrizio Cavallaro   +10 more
wiley   +1 more source

Auditory temporal resolution threshold in elderly individuals [PDF]

open access: yes, 2010
TEMA: o Teste de Detecção de Intervalo Aleatório - Random Gap Detection Test (RGDT) avalia o limiar de resolução temporal. Existem dúvidas se à medida que o sujeito envelhece, seu desempenho nesta tarefa se mantém inalterada.
BRANCO-BARREIRO, Fátima Cristina Alves   +2 more
core   +2 more sources

Albumin Folding Changes Affect the Microfluidic Interfacial Broadening Revealed by Surface Plasmon Resonance

open access: yesChemistry–Methods, Volume 5, Issue 3, March 2025.
The manuscript introduces a new methodology using Surface Plasmon Resonance (SPR) coupled with stochastic simulations. It reveals albumin′s conformational changes by tracking its diffusion coefficient (D). This approach monitors albumin′s structure in real time under various conditions, including enzymatic cleavage. The findings offer new insights into
Damiano Calcagno   +6 more
wiley   +1 more source

Efeito da anestesia geral na cognição e na memória do idoso Efecto de la anestesia general en la cognición y memoria del paciente de edad avanzada Effects of general anesthesia in elderly patients’ memory and cognition

open access: yesRevista Brasileira de Anestesiologia, 2004
JUSTIFICATIVA E OBJETIVOS: A anestesia geral e a função mental têm sido alvo de estudos e considerações, especialmente pelo sentimento de que ela, particularmente em idosos, poderia induzir alterações na cognição e na memória.
Régis Borges Aquino   +3 more
doaj   +1 more source

Inspecção do sistema nervoso central em pequenos ruminantes [PDF]

open access: yes, 2010
O Scrapie é uma doença neurodegenerativa fatal que afecta ovinos e caprinos e é a forma mais comum das Encefalopatias Espongiformes Transmissíveis (EET's), que incluem a doença de Creutzfeldt – Jakob (CJD), em humanos, e a Encefalopatia Espongiforme ...
Esteves, Fernando   +3 more
core  

Otoneurological findings in an inflammatory myopathy case [PDF]

open access: yes, 2012
BACKGROUND: polymyositis is an idiopathic systematic disease characterized by a non-suppurative inflammatory process which attacks the skeletal musculature and manifests itself clinically by proximal and symmetrical muscular debility. It shows a variable
Klagenberg, Karlin Fabianne   +4 more
core   +1 more source

Surface Plasmon Resonance Allows to Correlate Molecular Properties With Diffusion Coefficients of Linear Chain Alcohols

open access: yesChemistry – A European Journal, Volume 30, Issue 56, October 8, 2024.
This study introduces a new model to describe and fit the behavior of diffusion coefficients (D) as a function of molecular structure and thermodynamic parameters in binary solutions of linear chain organic molecules. The model is validated using surface plasmon resonance (SPR) experiments and molecular dynamics (MD) simulations for a series of n ...
Giuseppe Stefano Basile   +7 more
wiley   +1 more source

Meningite por linfoma primitivo do sistema nervoso central: relato de um caso

open access: yesArquivos de Neuro-Psiquiatria, 1977
É relatado o caso de uma paciente com 17 anos de idade que apresentou uma síndrome meningítica sem etiologia definida. Recebeu tratamento para meningite purulenta, tuberculosa e fúngica.
Lineu Cesar Werneck   +3 more
doaj   +1 more source

LEUCONOSTOC, UMA INFECÇÃO RARA EM SISTEMA NERVOSO CENTRAL

open access: yesBrazilian Journal of Infectious Diseases, 2022
Introdução: Paciente diagnosticado com hemorragia intraventricular submetido a derivação ventricular externa (DVE), internado em unidade de terapia intensiva (UTI), evolui com meningite por um raro microrganismo não pertencente a microbiota humana, o ...
Taynara Melchior Fratoni   +2 more
doaj   +1 more source

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