Results 221 to 230 of about 18,693 (245)

Sister chromatid cohesion halts DNA loop expansion

Molecular Cell
Eukaryotic genomes are folded into DNA loops mediated by structural maintenance of chromosomes (SMC) complexes such as cohesin, condensin, and Smc5/6. This organization regulates different DNA-related processes along the cell cycle, such as transcription, recombination, segregation, and DNA repair.
Bastié, Nathalie, Chapard, Christophe, Cournac, Axel, Nejmi, Sanae, Mboumba, Henri, Gadal, Olivier, Thierry, Agnès, Beckouët, Frederic, Koszul, Romain   +8 more
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Analyzing Sister Chromatid Cohesion in Mammalian Cells

2014
The metaphase chromosome spread technique and subsequent analysis of sister chromatid cohesion is used for (clinical) diagnosis of genetic abnormalities that can cause aberrant sister chromatid cohesion. In addition, the technique can be used to assess the contribution of novel genes to the cohesion establishment and maintenance pathways.
Katherine M, Feeney, Laura, McFarlane-Majeed, Joanna L, Parish   +2 more
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Sister chromatid cohesiveness: Vital function, obscure mechanism

Biochemistry and Cell Biology, 1990
Observations of chromosome behavior have suggested that it is sister chromatid cohesiveness which is primarily responsible for maintenance of chiasmate association between pachytene and anaphase of the first meiotic division and also for maintenance of sister centromere association until anaphase II.
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Heterochromatin and the cohesion of sister chromatids

Chromosome Research, 2009
Heterochromatin, once thought to be the useless junk of chromosomes, is now known to play significant roles in biology. Underlying much of this newfound fame are links between the repressive chromatin structure and cohesin, the protein complex that mediates sister chromatid cohesion.
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Calpain 2 is required for sister chromatid cohesion

Chromosoma, 2010
Calpains form a family of Ca(2+)-dependent cysteine proteases involved in diverse cellular processes. However, the specific functions of each calpain isoform remain unknown. Recent reports have shown that calpain 2 (Capn2) is essential for cell viability. We have recently shown that Capn2 is a nuclear protease associated with chromosomes during mitosis
Magnaghi-Jaulin, Laura, Marcilhac, Anne, Rossel, Mireille, Jaulin, Christian, Benyamin, Yves, Raynaud, Fabrice   +5 more
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Replication-Related Activities Establish Cohesion Between Sister Chromatids

Cell Biochemistry and Biophysics, 2001
Replicated sister chromatids are held together from their synthesis in S phase to their separation in anaphase. The process of sister chromatid cohesion is essential for the proper segregation of chromosomes in eukaryotic cells. Recent studies in Saccharomyces cerevisiae have advanced our understanding of how sister chromatid cohesion is established ...
Z, Wang, M F, Christman
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Buck the establishment: reinventing sister chromatid cohesion

Trends in Cell Biology, 2010
The time between chromosome replication and segregation can be from hours to decades. Cohesion is thus crucial for identifying replication products as sister chromatids from S-phase until mitosis. Early models posited active sister chromatid tethering reactions in which cohesins deposited onto each sister chromatid are converted to a paired state by ...
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Sister chromatid cohesion along arms and at centromeres

Trends in Genetics, 2005
There is an obvious difference between the regulation of sister chromatid cohesion at centromeres and along chromosome arms during meiosis, because centromeric cohesion, but not arm cohesion, persists throughout anaphase of the first meiotic division. This regional difference of sister chromatid cohesion is also observed during mitosis; the cohesion is
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Cohesion by topology: sister chromatids interlocked by DNA.

Genes & development, 2008
Sister chromatid cohesion is coupled with chromosome replication and influences chromosome segregation and intra-S repair. Specialized proteins, the cohesins, together with other pathways contribute to tether sister chromatids. In this issue of Genes & Development, Wang and colleagues (pp. 2426-2433 demonstrate that TopoIV, a type II DNA topoisomerase,
R. Bermejo, D. Branzei, M. Foiani
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Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I

Nature, 2006
Christian G Riedel, Takehiko Itoh, Mark Petronczki   +2 more
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