Results 111 to 120 of about 30,111 (196)

Differential condensation of sister chromatids acts with Cdc6 to ensure asynchronous S-phase entry in Drosophila male germline stem cell lineage. [PDF]

Dev Cell, 2022
Ranjan R, Snedeker J, Wooten M, Chu C, Bracero S, Mouton T, Chen X.   +6 more
europepmc   +1 more source

Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay

Nature Communications, 2017
The spindle assembly checkpoint delays mitotic progression until sister chromatids are bi-oriented. Here the authors show that moderate delays in mitotic progression induce centrosome fragmentation and centriole disengagement and that spindle bipolarity ...
Menuka Karki, Neda Keyhaninejad, Charles B. Shuster   +2 more
doaj   +1 more source

Mps1 kinase-dependent Sgo2 centromere localisation mediates cohesin protection in mouse oocyte meiosis I

Nature Communications, 2017
In meiosis I centromeric cohesin is protected by Sgo2 from Separase-mediated cleavage ensuring that sister chromatids are kept together until their separation in meiosis II.
Warif El Yakoubi, Eulalie Buffin, Damien Cladière, Yulia Gryaznova, Inés Berenguer, Sandra A. Touati, Rocío Gómez, José A. Suja, Jan M. van Deursen, Katja Wassmann   +9 more
doaj   +1 more source

Meiosis-specific distal cohesion site decoupled from the kinetochore

Nature Communications
Primary constriction of the M-phase chromosome serves as a marker for the kinetochore position. Underlying this observation is the concept that the kinetochore is spatially linked with the pericentromere where sister-chromatids are cohered. Here, we find
Bo Pan, Melania Bruno, Todd S. Macfarlan, Takashi Akera   +3 more
doaj   +1 more source

Kinetic control of eukaryotic chromatin structure by recursive topological restraints [PDF]

, 2008
Chromatin structure undergoes many changes during the cell cycle and in response to regulatory events. A basic unit of chromatin organization is the nucleosome core particle.
Dominika Borek, Zbyszek Otwinowski
core   +1 more source

Substrate accessibility regulation of human TopIIa decatenation by cohesin

Nature Communications
Human topoisomerase II alpha (TOP2α) resolves DNA intertwines between sister chromatids during mitosis. How cohesin, an SMC complex that holds sister chromatids, affects TOP2α decatenation is unclear. To addres this, we developed a quadruple-trap optical
Erin E. Cutts, Sanjana Saravanan, Paul Girvan, Benjamin Ambrose, Gemma L. M. Fisher, David S. Rueda, Luis Aragon   +6 more
doaj   +1 more source

Conformation of sister chromatids in the replicated human genome. [PDF]

Nature, 2020
Mitter M, Gasser C, Takacs Z, Langer CCH, Tang W, Jessberger G, Beales CT, Neuner E, Ameres SL, Peters JM, Goloborodko A, Micura R, Gerlich DW.   +12 more
europepmc   +1 more source

Detecting chromatin interactions between and along sister chromatids with SisterC. [PDF]

Nat Methods, 2020
Oomen ME, Hedger AK, Watts JK, Dekker J.
europepmc   +1 more source

DNA repair is efficient in irradiated M phase zygotes

The Journal of Reproduction and Development
In somatic cells, DNA repair is attenuated during mitosis to prevent the formation of anaphase bridges and facilitate the proper segregation of sister chromatids. Irradiation-induced γH2AX foci persist for hours in M phase somatic cells.
Yuan WANG, Dai TSUKIOKA, Shoji ODA, Hiroshi MITANI, Fugaku AOKI   +4 more
doaj   +1 more source

Molecular basis of heavy-chain class switching and switch region deletion in an Abelson virus-transformed cell line [PDF]

, 1984
We demonstrated that a subclone of an Abelson murine leukemia virus-transformed B-lymphoid cell line switched from mu to gamma 2b expression in vitro, by the classical recombination-deletion mechanism.
Alt, Frederick W., Andrews, Nancy, Baltimore, David, DePinho, Ronald, Kruger, Kelly, Lutzker, Stuart   +5 more
core