Genome-wide mapping of sister chromatid exchange events in single yeast cells using Strand-seq [PDF]
eLife, 2017 Homologous recombination involving sister chromatids is the most accurate, and thus most frequently used, form of recombination-mediated DNA repair. Despite its importance, sister chromatid recombination is not easily studied because it does not result ...
Clémence Claussin +7 more
doaj +2 more sources
Cell Cycle Kinetics and Sister Chromatid Exchange in Mosaic Turner Syndrome [PDF]
LifeTurner syndrome (TS) is caused by a complete or partial absence of an X or Y chromosome, including chromosomal mosaicism, affecting 1 in 2500 female live births.
Miriam Beatriz Goulart +10 more
doaj +2 more sources
Automatic detection of sister chromatid exchanges using machine learning models and image analysis algorithms [PDF]
Scientific ReportsAfter DNA replication, two chromatids with identical genetic information are formed in organisms; these are called sister chromatids. Sister chromatid exchange (SCE) is a recombination event between genetically equivalent sequences.
Mizuo Teraoka +5 more
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Elevated rates of sister chromatid exchange at chromosome ends. [PDF]
PLoS Genetics, 2007 Chromosome ends are known hotspots of meiotic recombination and double-strand breaks. We monitored mitotic sister chromatid exchange (SCE) in telomeres and subtelomeres and found that 17% of all SCE occurs in the terminal 0.1% of the chromosome ...
M Katharine Rudd +5 more
doaj +2 more sources
Effect of borax on immune cell proliferation and sister chromatid exchange in human chromosomes [PDF]
Journal of Occupational Medicine and Toxicology, 2009 Background Borax is used as a food additive. It becomes toxic when accumulated in the body. It causes vomiting, fatigue and renal failure. Methods The heparinized blood samples from 40 healthy men were studied for the impact of borax toxicity on immune ...
Pongsavee Malinee
doaj +2 more sources
DNA-PK-dependent RPA2 hyperphosphorylation facilitates DNA repair and suppresses sister chromatid exchange. [PDF]
PLoS ONE, 2011 Hyperphosphorylation of RPA2 at serine 4 and serine 8 (S4, S8) has been used as a marker for activation of the DNA damage response. What types of DNA lesions cause RPA2 hyperphosphorylation, which kinase(s) are responsible for them, and what is the ...
Hungjiun Liaw +2 more
doaj +2 more sources
Distribution and sources of variability of sister-chromatid exchange frequencies in cattle* [PDF]
Genetics Selection Evolution, 1994 Arruga MV, Moreno C, Catalán J
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Chromosomal integrity after UV irradiation requires FANCD2-mediated repair of double strand breaks [PDF]
, 2016 Fanconi Anemia (FA) is a rare autosomal recessive disorder characterized by hypersensitivity to inter-strand crosslinks (ICLs). FANCD2, a central factor of the FA pathway, is essential for the repair of double strand breaks (DSBs) generated during fork ...
Bocco, Jose Luis +7 more
core +17 more sources
Smoking and sister chromatid exchange [PDF]
Hereditas, 2009 The present survey comprises analysis of sister chromatid exchange (SCE) frequencies in the peripheral blood lymphocytes of 100 subjects: 83 healthy men and women, both cigarette smokers and nonsmokers and 17 children. Both for men (30 smoking, 22 nonsmoking) and for women (13 smoking, 18 nonsmoking) the frequency of SCEs is significantly higher among ...
K, Husgafvel-Pursiainen +3 more
openaire +2 more sources
Rescue of collapsed replication forks is dependent on NSMCE2 to prevent mitotic DNA damage. [PDF]
PLoS Genetics, 2019 NSMCE2 is an E3 SUMO ligase and a subunit of the SMC5/6 complex that associates with the replication fork and protects against genomic instability. Here, we study the fate of collapsed replication forks generated by prolonged hydroxyurea treatment in ...
Kelvin W Pond +3 more
doaj +1 more source