Journal of Applied Toxicology, EarlyView.ABSTRACT Children, as a particularly vulnerable group, are more susceptible to these mutagens due to their developing immune systems, higher physiological vulnerability, and increased exposure through behaviors like outdoor play and hand‐to‐mouth activities. This review aims to investigate the relationship between these environmental exposures, genetic
Thiago Guedes Pinto +7 more
wiley +1 more source
Chromosome fragility in Freemartin cattle
Italian Journal of Animal Science, 2010 The aim of the present study was to verify chromosome fragility in freemartin cattle using chromosome aberration (CA) and sister chromatid exchange (SCE) tests. A total of eighteen co-twins were investigated.
V. Barbieri +7 more
doaj +1 more source
Mouse RAD54 affects DNA double-strand break repair and sister chromatid exchange [PDF]
, 2000 Cells can achieve error-free repair of DNA double-strand breaks (DSBs) by homologous recombination through gene conversion with or without crossover.
Beverloo, H.B. (Berna) +5 more
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Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review
Phytotherapy Research, EarlyView.ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley +1 more source
Evulation of Antimutagenic Activity of Ni(II) Complexes with Unsymmetric Schiff Bases
Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2020 In this work, Ni(II) complexes with unsymmetricSchiff bases (NiL1, NiL2, NiL3, NiL4)wereprepared by a two-stage method reported by one of us recently forinvestigate antimutagenic properties.
Hamit Emre Kızıl +4 more
doaj +1 more source
Homologous Recombination: To Fork and Beyond [PDF]
, 2018 Accurate completion of genome duplication is threatened by multiple factors that hamper the advance and stability of the replication forks. Cells need to tolerate many of these blocking lesions to timely complete DNA replication, postponing their repair ...
Prado Velasco, José Félix
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Safety Evaluation of an Aqueous Root and Leaf Extract of Ashwagandha (Withania somnifera)
Phytotherapy Research, EarlyView.Sensoril, an aqueous root and leaf extract of ashwagandha showed no evidence of mutagenicity in the in vitro Ames assay, was negative in the in vitro micronucleus, in vivo mammalian bone marrow chromosome aberration assays, and was well tolerated in the rat at up to 4000 mg/kg BW/day when administered orally for a period of 90 days. The data from these
Mukesh Summan +2 more
wiley +1 more source
Comparison of genome stability in two pig breeds by using the sister chromatid exchange (SCE) test
Italian Journal of Animal Science, 2010 The sister chromatid exchange (SCE) test has been used to detect genome stability in humans (Chaganti, 1974) and the main livestock species (Ciotola et al., 2004; Di Meo et al., 2000; Di Berardino et al., 1979), and to discover DNA damage caused by a ...
V. Barbieri +5 more
doaj +1 more source
Genetic damage in New Zealand Vietnam War veterans : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Genetics at Massey University, Palmerston North, New Zealand [PDF]
, 2006 Accompanying CD-ROM contains the complete SCE results for all participants System requirement Microsoft ExcelFrom July 1965 until May 1971, New Zealand Defence Force Personnel fought in the Vietnam War. During this time the United States military forces
Edwards, Louise Ann
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Chronic ethanol consumption in mice does not induce DNA damage in somatic or germ cells, evaluated by the bone marrow micronucleous assay and the dominant lethal mutation assay [PDF]
, 2012 Indexación: Web of Science; ScieloAlthough alcohol is known to be a carcinogen for humans, ethanol-genotoxicity studies are incomplete. Ethanol seems not to be a bacterial mutagen, but the results are conflicting in rodent assays.
Ellahueñe, Manuel +2 more
core +1 more source