Results 61 to 70 of about 22,194 (215)

Precocious activation of APC/C-Cdh1 at pre-anaphase causes genome instability [PDF]

, 2008
Faithful chromosome segregation and thereby accurate gene transmission are crucial for all organisms. Until proper attachment of the mitotic spindle to the kinetochore is established, the ubiquitin ligase (E3) Cdc20-activated APC/C (anaphase promoting ...
Asuka Suzuki, Ayumu Yamamoto, Kazuhiro Toda, Masahiro Uritani, Masaru Ueno, Takanori Ohyoshi, Takashi Ushimaru   +6 more
core   +1 more source

Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion [PDF]

, 2019
Genome stability involves accurate replication and DNA repair. Broken replication forks, such as those encountering a nick, lead to double strand breaks (DSBs), which are preferentially repaired by sister-chromatid recombination (SCR).
Aguilera López, Andrés, Gómez González, Belén, Ortega Moreno, Pedro   +2 more
core   +1 more source

Errors in chromosome segregation during oogenesis and early embryogenesis [PDF]

, 2010
Errors in chromosome segregation occurring during human oogenesis and early embryogenesis are very common. Meiotic chromosome development during oogenesis is subdivided into three distinct phases.
A Dyban, A Kuliev, A Kuliev, A Mantzouratou, A Pujol, AL Barlow, C Gutierrez-Mateo, C Gutierrez-Mateo, C Staessen, C Tease, C Tease, C Tease, C Yuncken, CM Conn, CM Conn, D Wells, D Wells, E Bendsen, E Fragouli, E Fragouli, E Fragouli, E Fragouli, E Iwarsson, EY Cheng, F Pellestor, F Pellestor, G Sher, HE Hall, J Cohen, J Cozzi, JD Delhanty, JD Delhanty, JD Delhanty, JD Delhanty, KT Jones, L Gianaroli, L Gras, L Voullaire, L Voullaire, L Wilton, M Hultén, M Sandalinas, M Simopoulou, MA Hultén, ML Lenzi, NV Kovaleva, P Platteau, PA Almeida, PA Hunt, R Angell, R Mahmood, S Cupisti, S Evsikov, S Mastenbroek, S Munné, S Munné, S Munné, S Munné, S Munné, S Munné, S Munné, S Munné, T Anahory, T Hassold, TR Oliver, Y Verlinsky   +65 more
core   +1 more source

Flavouring Group Evaluation 82 Revision 2 (FGE.82Rev2): Consideration of epoxides evaluated by JECFA

EFSA Journal, Volume 24, Issue 4, April 2026.
Abstract The Panel on Food Additives and Flavourings (FAF) of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), and to decide whether further evaluation is necessary, as laid down in Commission Regulation (EC) No.
EFSA Panel on Food Additives and Flavourings (FAF), Laurence Castle, Monica Andreassen, Gabriele Aquilina, Maria Bastos, Polly Boon, Biagio Fallico, Rex FitzGerald, María José Frutos Fernández, Bettina Grasl‐Kraupp, Ursula Gundert‐Remy, Rainer Gürtler, Eric Houdeau, Marcin Kurek, Henriqueta Louro, Patricia Morales, Sabina Passamonti, Gisela Degen, Karl‐Heinz Engel, Maria Carfí, Ana Criado, Borana Dino, Carla Martino   +22 more
wiley   +1 more source

Investigation on the Genotoxicity of Mercuric Chloride to Freshwater Clarias gariepinus [PDF]

Pakistan Veterinary Journal, 2014
The cytogenetic effect of heavy metal was studied in Clarias gariepinus using the micronucleus test, chromosomal aberrations and sister chromatid exchange.
Shahid Mahboob, Hmoud Fares Alkkahem Al-Balwai, Fahad Al-Misned and Zubair Ahmad
doaj  

Aging and Immortality in a Cell Proliferation Model

, 2008
We investigate a model of cell division in which the length of telomeres within the cell regulate their proliferative potential. At each cell division the ends of linear chromosomes change and a cell becomes senescent when one or more of its telomeres ...
Abramowitz, Bailey, Bailey, Bryan, Campisi, Campisi, Campisi, Carey, Fleming, Gikhman, Gradshteyn, Harley, Hasenmaile, Hayflick, Henson, K.B. Blagoev, Karlin, Nisbet, Olovnikov, Reddel, Redner, S. Redner, S.A. Trugman, Steinsaltz, T. Antal, Watson, Weitz   +26 more
core   +1 more source

Global Burden of Lead Exposure: Integrating Epidemiology, Molecular Mechanisms, and Mitigation Approaches

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Lead is a nonessential, toxic heavy metal that causes widespread environmental contamination, affecting humans, animals, plants, and ecosystems. Globally, an estimated 800 million children have blood lead levels (BLLs) above 5 µg/dL.
Gudisa Bereda
wiley   +1 more source

Mussel eggs as indicators of mutagen exposure in coastal and estuarine environments [PDF]

, 1994
The aim of this study was to develop a short-term genotoxicity assay for monitoring the marine environment for mutagens. Based on the developing eggs and embryos of the marine mussel Mytilus edulis, an important pollution indicator species, the test ...
Dixon, D.R., Pascoe, P.L
core  

Therapeutic Gene Editing: DNA Repair Pathways, Emerging Editors, and Clinical Progress

iNew Medicine, Volume 2, Issue 1, March 2026.
ABSTRACT The field of gene editing has evolved rapidly over the past decade, progressing from programmable zinc‐finger nucleases (ZFNs) and transcription activator‐like effector nucleases (TALENs) to the widespread adoption of CRISPR‐Cas systems. First‐generation editors catalyzed genome engineering by introducing targeted double‐strand breaks (DSBs ...
Li‐Kuang Tsai, Youcai Xiong, Dongqi Liu, Dongshan Yang, Jifeng Zhang, Jie Xu, Renzhi Han, Y. Eugene Chen   +7 more
wiley   +1 more source

Graphene Triggers Inflammation in Murine Microglia via Phagocytosis

Small Science, Volume 6, Issue 3, March 2026.
Phagocytosis of single‐layer graphene by microglia triggers inflammatory activation without cytotoxicity. Small carbon nanotubes elicit similar responses, whereas larger graphene nanoplatelets do not. Proteomic analysis reveals effects on inflammation, cytoskeleton, and proliferation, highlighting the importance of graphene stability for safe neural ...
Pratika Rai, Robert Subirana Slotos, Ahmar Hasnain, Emma Walter, Marina Mantellatto Grigoli, Irini Petrou, Mario Dejung, Jia‐Xuan Chen, Oliver Tüscher, Alexey Tarasov, Kristina Endres   +10 more
wiley   +1 more source