Results 141 to 150 of about 303,411 (311)

ArcGIS Server per la distribuzione delle informazioni del Trasporto Pubblico

GEOmedia, 2012
Uno degli obiettivi di ATAC, gestore del trasporto pubblico del Comune di Roma, è quello di fornire informazioni sul trasporto pubblico ad un bacino di utenza sempre più vasto.
Flaminia Leggeri, Patrizia Micheli, Annalisa Perla   +2 more
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Educating Policy Advocates – Current and Potential Roles for SIT and World Learning

, 2010
The session will focus on ways that we are now engaged and could become more engaged in educating students and civil society leaders to influence the policies of governments, international organizations, corporations and other institutions of political ...
Curry-Smithson, Charlie, PhD, Professor, Unsicker, Jeff, PhD, Professor   +1 more
core  

Effectiveness of sprint interval training in enhancing adolescent physical fitness: a systematic review and meta-analysis. [PDF]

PeerJ
Xu T, Su S.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Leveraging antisolvent-processed β-sitosterol to construct a multifunctional curcumin-loaded oleogel for diabetic wound healing. [PDF]

Mater Today Bio
Guo H, Deng S, Huang C, Zheng J, Ou J, Liu Z, Ou S, Liu F.   +7 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Five Weeks of Sprint Interval Training Increase Absolute Power Output Within Severe-Intensity Domain Without Altering Muscle Activation or Fatigability. [PDF]

Eur J Sport Sci
de Poli RAB, Murias JM, Dutra YM, Zagatto AM.   +3 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Can Changes in Sit-To-Stand Performance Throughout A 30-S Time Interval Be Used as A Marker of Performance Fatigability in Middle-Aged To Older Adults? [PDF]

J Sports Sci Med
Riesbeck M, Löppönen A, Deboutte J, Delecluse C, Palmberg L, Van Roie E.   +5 more
europepmc   +1 more source