Results 201 to 210 of about 2,059,602 (326)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Moderators of body composition change in response to sprint interval training versus moderate-intensity continuous training: a systematic review and meta-regression analysis. [PDF]

BMC Public Health
Liang W, Yan X, Zhao L, Xu S, Liu C, Huang W.   +5 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Sit-to-Stand Power From 2D Pose Estimation as an Indicator of Muscle Strength in Older Adults. [PDF]

J Cachexia Sarcopenia Muscle
Hwang W, Shim D, Kim J, Oh KR, Chung SG, Beom J, Park MW, Kim KS, Kim J, Park CH, Kim K.   +10 more
europepmc   +1 more source

Stopping to Sit

Academic Medicine, 2020
openaire   +3 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Athletic participation and its impact on self-concept, body image, and physical fitness in Saudi female adolescents: a cross-sectional comparison between athletes and non-athletes. [PDF]

PeerJ
Alonazi A, Almutairi D, Alyousef T, Alkhateeb A.   +3 more
europepmc   +1 more source

Reducing children's classroom sitting time using sit-to-stand desks: findings from pilot studies in UK and Australian primary schools.

Journal of public health, 2016
S. Clemes, S. Barber, D. Bingham, N. Ridgers, Elly A. Fletcher, N. Pearson, J. Salmon, D. Dunstan   +7 more
semanticscholar   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Comparative effects of high-intensity and sprint interval training on cardiorespiratory fitness and body composition: a systematic review with meta-analysis. [PDF]

Front Physiol
Zhang D, Dong J, Hou CW, Wang JP.
europepmc   +1 more source