Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Un sistema informativo territoriale 3D degli ostacoli alla navigazione aerea
I campi d’applicazione dei Sistemi Informativi Territoriali divengono via via sempre più vasti ed eterogenei, per numerose motivazioni. Se, da una parte, è innegabile un interesse sempre crescente da parte di enti pubblici e/o privati che operano sul ...
Antonio Condorelli +2 more
doaj
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Investigation of the Specific Ion Interactions and Determining Protonation Constant of 3,5-Dihydroxy-2-(3,4,5-trihydroxybenzoyl)oxy-6-[(3,4,5-trihydroxybenzoyl)oxymethyl] oxan-4-yl] 3,4,5-trihydroxybenzoate at Different Ionic Strength [PDF]
In this research, the protonation constant value of tannic acid was determined at 25 °C and different ionic strengths (0.1 to 0.7 mol/dm3 NaCl) using potentiometric titration technique. The dependence of protonation constant on ionic strength was modeled
Gholamreza Ebrahimzadeh Rajaei +1 more
doaj
The microbiome in human skin aging
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
A young female performing a sit to stand from a high chair
Video clip: sit to stand, a high chair, performed by a young female with a chair recorded from the side view.; Task: sit to stand, high chair.; Actor: young female.; Equipment: chair.
Biomechanics Research Laboratory (University of Southern California)
core +1 more source
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
This paper is an examination of five case studies of international students who participated in the Program for Intercultural Service, Leadership, and Management (PIM) at the School for International Training (SIT).
Syrotiak, Mariana Palade
core +2 more sources
Pilot implementation and evaluation of the Sit-Stand e-Guide: an e-training program on the use of sit-stand workstations [PDF]
The ‘Sit-Stand e-Guide’ e-training program, designed to promote appropriate use of sit-stand workstations (SSWs), was evaluated for usability, acceptability and impact on various outcomes among SSW users. Participants from a large municipal organisation (
Goode, Ana D. +3 more
core +1 more source

