Results 161 to 170 of about 23,280 (257)

Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes.

New England Journal of Medicine, 2015
J. Green, M. Bethel, P. Armstrong, J. Buse, S. Engel, J. Garg, R. Josse, K. Kaufman, J. Koglin, S. Korn, J. Lachin, Darren K Mcguire, M. Pencina, E. Standl, P. Stein, S. Suryawanshi, F. Van de Werf, E. Peterson, R. Holman, Theodora S Temelkova-Kurktschiev   +19 more
semanticscholar   +1 more source

Sitagliptin eye drops prevent the impairment of retinal neurovascular unit in the new Trpv2 +/− rat model

Journal of Neuroinflammation
Impaired function of the retinal neurovascular unit (NVU) is an early event in diabetic retinopathy (DR). It has been previously shown that topical delivery of the dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin can protect against diabetes-mediated
Hugo Ramos, Josy Augustine, Burak M. Karan, Cristina Hernández, Alan W. Stitt, Tim M. Curtis, Rafael Simó   +6 more
doaj   +1 more source

Sitagliptin accelerates restoration of normal blood glucose levels.

, 2013
(A) C57Bl6 mice were treated with a single dose of streptozotocin (180 mg/kg) and placed on either a normal chow diet or diet containing 5.5% sitagliptin following syngeneic islet transplantation (day 0).
Neelam Lingwal (183259), Felix B. Engel (251659), Balaji Samikannu (495828), Manju Padmasekar (495829), Chunguang Chen (371632), Thomas Linn (371640)   +5 more
core   +1 more source

Sitagliptin and Simvastatin Interaction Causing Rhabdomyolysis and AKI

, 2019
We report a case of rhabdomyolysis and severe acute kidney injury (AKI) requiring dialysis in a 69-year-old male who was recently started on sitagliptin while on chronic simvastatin therapy.
Yousef Hattab, Courtney Thompson, Megan Copley-Harris, Chinmay Patel   +3 more
core   +1 more source

Asymmetric synthesis of (-)-(R)-sitagliptin

, 2012
The asymmetric synthesis of (-)-(R)-sitagliptin was achieved in seven steps from commercially available starting materials using the highly diastereoselective conjugate additions of either lithium (R)-N-benzyl-N- (α-methylbenzyl)amide or lithium (R)-N ...
Paul M. Roberts, Stephen G. Davies, Ai M. Fletcher, James E. Thomson, Roberts, PM, Thomson, JE, Lv, L, Davies, SG, Thomson, James, Linlu Lv, Davies, Stephen, Fletcher, AM, Roberts, Paul   +12 more
core   +1 more source

Comparison of sitagliptin monotherapy with combination therapy

, 2018
Çalışmamızda sitagliptinin monoterapide ve kombinasyon (metformin veya pioglitazon) tedavilerinde kullanımlarının glisemik kontrol, lipid profili ve insülin direnci üzerine etkilerinin karşılaştırılması amaçlanmıştır.
Şişman, Pınar
core  

Electrochemical Synthesis of a Sitagliptin Precursor

A novel synthesis of sitagliptin based on a redox-active ester derived from the chiral pool is reported. The key step is an electrochemical nickel-catalyzed sp2-sp3 cross-coupling reaction using inexpensive nickel foam in an undivided cell.
Elisabeth K. Oehl (18435523), María Méndez (3685621), Siegfried R. Waldvogel (1434088), Sven Ruf (2030305), Paul T. Jirsch (18435526), Jasmin Hammes (16661576), Andreas Stenglein (4001738)   +6 more
core   +1 more source

Pharmacokinetic and pharmacodynamic evaluation of sitagliptin plus metformin.

, 2010
peer reviewedIMPORTANCE OF THE FIELD: Type 2 diabetes is an increasingly prevalent disease resulting from various complex combinations of defects in insulin secretion and insulin action.
Scheen, André, André J Scheen
core   +1 more source

(A) Confocal images represent insulin (red) immunostained pancreas sections from diabetic mice treated with vehicle, PSN632408, sitagliptin, or PSN632408 plus sitagliptin.

, 2013
(B) Quantification of β-cell mass in the pancreases of non-diabetic control mice and diabetic mice with restored normoglycemia after 7 weeks of treatment with PSN632408, sitagliptin, or PSN632408 and sitagliptin combination (3 to 4 mice per group).
Ansarullah (286218), Brittany DeRuyter (286222), Zhiguang Guo (286226), Alex Rabinovitch (286224), Martha Holstein (286220), Yan Lu (32611)   +5 more
core   +1 more source

Effect of Sitagliptin and Vitamin D3 on Secretion of IL-6 and TNF-α Inflammatory Factors in Patients with Type 2 Diabetes

پزشکی بالینی ابن سینا, 2018
Background and Objective: Diabetes mellitus is one of the most commonly reported diseases that is associated with insulin resistance and increased blood glucose levels.
Elham Mahabadi-Ashtiyani, Vida Sheikh, Shiva Borzouei, Iraj Salehi, Mahdi Alahgholi-Hajibehzad   +4 more
doaj