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Metformin Hydrochloride and Sitagliptin Phosphate Fixed-Dose Combination Product Prepared Using Melt Granulation Continuous Processing Technology [PDF]
AAPS PharmSciTech, 2019 The development of oral solid dosage forms, such as tablets that contain a high dose of drug(s), requires polymers and other additives to be incorporated at low levels as possible, to keep the final tablet weight low, and, correspondingly, the dosage ...
Jeremiah Kelleher +9 more
semanticscholar +6 more sources
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Analytical Methods, 2023
A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was used for the quantification of 7-nitroso-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine (NTTP) in the sitagliptin phosphate monohydrate active pharmaceutical ...
Zhen Wang +5 more
semanticscholar +1 more source
A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was used for the quantification of 7-nitroso-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine (NTTP) in the sitagliptin phosphate monohydrate active pharmaceutical ...
Zhen Wang +5 more
semanticscholar +1 more source
Current Pharmaceutical Analysis, 2023
Sitagliptin phosphate monohydrate-dapagliflozin propanediol hydrate fixeddose combination (FDC) dual-layered tablet is used for type 2 diabetes treatment.
Joo-Eun Kim, So-Jin Kang
semanticscholar +1 more source
Sitagliptin phosphate monohydrate-dapagliflozin propanediol hydrate fixeddose combination (FDC) dual-layered tablet is used for type 2 diabetes treatment.
Joo-Eun Kim, So-Jin Kang
semanticscholar +1 more source
Research Journal of Pharmacy and Technology, 2023
For multicomponent pharmaceutical dosage forms, simultaneous equation method has emerged out as boon with lots of advantages like easy, rapid and sensitive method.
Akanksha Dwivedi, R. Sharma
semanticscholar +1 more source
For multicomponent pharmaceutical dosage forms, simultaneous equation method has emerged out as boon with lots of advantages like easy, rapid and sensitive method.
Akanksha Dwivedi, R. Sharma
semanticscholar +1 more source
Current Pharmaceutical Analysis, 2023
Recently, a combination prescription with the main ingredients sitagliptin and dapagliflozin as dipeptidyl peptidase-4 andsodium–glucose cotransporter-2 inhibitors, respectively, for the treatment of type 2 diabetes has widely been issued in hospitals.
Ji-Hye Shin, Joo-Eun Kim
semanticscholar +1 more source
Recently, a combination prescription with the main ingredients sitagliptin and dapagliflozin as dipeptidyl peptidase-4 andsodium–glucose cotransporter-2 inhibitors, respectively, for the treatment of type 2 diabetes has widely been issued in hospitals.
Ji-Hye Shin, Joo-Eun Kim
semanticscholar +1 more source
Hospital Pharmacy, 2007
Each month, subscribers to The Formulary Monograph Service receive five to six well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to your Pharmacy and Therapeutics Committee. Subscribers also receive monthly one-page summary monographs on the agents that are useful for agendas and ...
Dennis J. Cada +2 more
openaire +1 more source
Each month, subscribers to The Formulary Monograph Service receive five to six well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to your Pharmacy and Therapeutics Committee. Subscribers also receive monthly one-page summary monographs on the agents that are useful for agendas and ...
Dennis J. Cada +2 more
openaire +1 more source
Biotechnology and Bioengineering, 2021
Here, we report a bienzymatic cascade to produce β‐amino acids as an intermediate for the synthesis of the leading oral antidiabetic drug, sitagliptin.
Taresh P. Khobragade +18 more
semanticscholar +1 more source
Here, we report a bienzymatic cascade to produce β‐amino acids as an intermediate for the synthesis of the leading oral antidiabetic drug, sitagliptin.
Taresh P. Khobragade +18 more
semanticscholar +1 more source
Efficient stereocontrolled synthesis of sitagliptin phosphate
Tetrahedron: Asymmetry, 2014Abstract The synthesis of sitagliptin phosphate 1 , a novel DPP-IV inhibitor for the treatment of type 2 diabetes mellitus has been accomplished starting from the chiral synthon (1,4-bis[( R )-1-phenylethyl]piperazine-2,5-dione) 2 , involving highly stereocontrolled (>98%) alkylation as a key step, in a good overall yield of 50% over six steps.
Chennam Setty Subbaiah, Wahajul Haq
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Journal of Pharma Insights and Research
A rapid, sensitive, and specific reverse-phase high-performance liquid chromatography (RP-HPLC) method was developed and validated for simultaneous estimation of Empagliflozin and Sitagliptin Phosphate in pharmaceutical formulations.
Syed Ansar Ahmed, Hrishikesh Kiran Puri
semanticscholar +1 more source
A rapid, sensitive, and specific reverse-phase high-performance liquid chromatography (RP-HPLC) method was developed and validated for simultaneous estimation of Empagliflozin and Sitagliptin Phosphate in pharmaceutical formulations.
Syed Ansar Ahmed, Hrishikesh Kiran Puri
semanticscholar +1 more source
Sitagliptin Phosphate Monohydrate
2011Biological target: Sitagliptin is a β-amino acid-derived inhibitor of dipeptidyl peptidase 4 (DPP4), a serine protease with membrane cell-signalling and soluble N-terminal proline peptidase activity. As a result, sitagliptin inhibits the in vivo degradation of the incretins, such as glucagon-like peptide-1 (GLP-1), which are endogenous glucoregulatory ...
Vitomir Šunjić, Michael J. Parnham
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