Results 71 to 80 of about 216 (92)
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Journal of Pharmaceutical Sciences
The solid form landscape of sitagliptin phosphate was systematically evaluated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy and X-ray powder diffraction (XRPD), supported by a plethora of auxiliary analytical techniques.
Jonathan B Lefton +2 more
exaly +3 more sources
The solid form landscape of sitagliptin phosphate was systematically evaluated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy and X-ray powder diffraction (XRPD), supported by a plethora of auxiliary analytical techniques.
Jonathan B Lefton +2 more
exaly +3 more sources
Current Pharmaceutical Analysis, 2023
Background: Recently, a combination prescription with the main ingredients sitagliptin and dapagliflozin as dipeptidyl peptidase-4 andsodium–glucose cotransporter-2 inhibitors, respectively, for the treatment of type 2 diabetes has widely been issued in hospitals.
Ji-Hye Shin, Joo-Eun Kim
openaire +1 more source
Background: Recently, a combination prescription with the main ingredients sitagliptin and dapagliflozin as dipeptidyl peptidase-4 andsodium–glucose cotransporter-2 inhibitors, respectively, for the treatment of type 2 diabetes has widely been issued in hospitals.
Ji-Hye Shin, Joo-Eun Kim
openaire +1 more source
Current Pharmaceutical Analysis, 2023
Background: Sitagliptin phosphate monohydrate-dapagliflozin propanediol hydrate fixeddose combination (FDC) dual-layered tablet is used for type 2 diabetes treatment. Simultaneous quantitative analysis can shorten the analysis time of sitagliptin phosphate monohydrate-dapagliflozin propanediol monohydrate FDC dual-layered tablets and increase their ...
So-Jin Kang, Joo-Eun Kim
openaire +1 more source
Background: Sitagliptin phosphate monohydrate-dapagliflozin propanediol hydrate fixeddose combination (FDC) dual-layered tablet is used for type 2 diabetes treatment. Simultaneous quantitative analysis can shorten the analysis time of sitagliptin phosphate monohydrate-dapagliflozin propanediol monohydrate FDC dual-layered tablets and increase their ...
So-Jin Kang, Joo-Eun Kim
openaire +1 more source
Analytical Methods, 2023
A fully validated LC-MS/MS method was developed for quantification of 7-nitroso-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine (NTTP) in sitagliptin phosphate monohydrate at LOQ of 0.098 ppm.
Zhen Wang +5 more
openaire +2 more sources
A fully validated LC-MS/MS method was developed for quantification of 7-nitroso-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine (NTTP) in sitagliptin phosphate monohydrate at LOQ of 0.098 ppm.
Zhen Wang +5 more
openaire +2 more sources
INDIAN DRUGS, 2014
A new RP-HPLC method for the quantitative determination of metformin and sitagliptin in human plasma was developed and validated as per US-FDA guidelines. The drug was spiked in the plasma and extracted with mobile phase by precipitation method. The extracted analyte was injected into Symmetry C18 (4.6 x 150 mm, 3.5μm, Make: XTerra) or equivalent ...
S. A Kumar +3 more
openaire +1 more source
A new RP-HPLC method for the quantitative determination of metformin and sitagliptin in human plasma was developed and validated as per US-FDA guidelines. The drug was spiked in the plasma and extracted with mobile phase by precipitation method. The extracted analyte was injected into Symmetry C18 (4.6 x 150 mm, 3.5μm, Make: XTerra) or equivalent ...
S. A Kumar +3 more
openaire +1 more source
Pakistan journal of pharmaceutical sciences, 2022
Reported high performance liquid chromatographic (HPLC) methods for estimating metformin hydrochloride (MET) and sitagliptin phosphate monohydrate (SIT) are either laborious or contain higher proportions of organic solvents in mobile phase, thus presenting exorbitant procedures.
Aqeela, Raza +8 more
openaire +1 more source
Reported high performance liquid chromatographic (HPLC) methods for estimating metformin hydrochloride (MET) and sitagliptin phosphate monohydrate (SIT) are either laborious or contain higher proportions of organic solvents in mobile phase, thus presenting exorbitant procedures.
Aqeela, Raza +8 more
openaire +1 more source
Powder Diffraction, 2015
The crystal structure of sitagliptin dihydrogen phosphate monohydrate (sometimes referred to as sitagliptin phosphate monohydrate) has been solved and refined using synchrotron X-ray powder diffraction data, and optimized using density functional techniques. Sitagliptin dihydrogen phosphate monohydrate crystallizes in space group
James A. Kaduk +3 more
openaire +1 more source
The crystal structure of sitagliptin dihydrogen phosphate monohydrate (sometimes referred to as sitagliptin phosphate monohydrate) has been solved and refined using synchrotron X-ray powder diffraction data, and optimized using density functional techniques. Sitagliptin dihydrogen phosphate monohydrate crystallizes in space group
James A. Kaduk +3 more
openaire +1 more source
International Journal of Drug Delivery Technology
An easy, specific, sensitive and reproducible RP-HPLC method has been developed and validated successfully for simultaneous quantitation of Metformin hydrochloride, Sitagliptin phosphate and Dapagliflozin monohydrate from tablet formulation. Chromatographic separation was performed on a C18 column under isocratic conditions using 0.02 M KH₂PO₄ buffer ...
Himanta Biswa Saikia +6 more
openaire +1 more source
An easy, specific, sensitive and reproducible RP-HPLC method has been developed and validated successfully for simultaneous quantitation of Metformin hydrochloride, Sitagliptin phosphate and Dapagliflozin monohydrate from tablet formulation. Chromatographic separation was performed on a C18 column under isocratic conditions using 0.02 M KH₂PO₄ buffer ...
Himanta Biswa Saikia +6 more
openaire +1 more source